Vascular trials

ARU and Mid and South Essex Vascular Unit unit collaborate in cutting edge peripheral vascular research, serving a population of 1.2 million people.

We are directly funded by the National Institute for Health Research (NIHR) and by industry to look at vascular health and technology.

Key investigators

Key collaborators

  • Mr Shiva Dindyal BORI
  • Mr Madhu Tiruveedhula
  • Dr Hilary Engward, VFI
  • Professor Alun Davies, Imperial College London
  • Dr Steven Rogers, University of Manchester

DUSTER feasibility RCT

This trial opening in 2025 examines the role of ultrasound surveillance after lower limb endovascular interventions in preventing major limb amputation.

IMPACT PAD NCT05035771

This feasibility study examines the safety and feasibility of flow and pressure measurements during lower limb endovascular intervention.

We have successfully performed the first in human case.

https://www.hra.nhs.uk/planning-and-improving-research/application-summaries/research-summaries/impact-pad-study/

Cerament - 2 study

This follow on study examines medium term clinical and radiological outcomes after using antibiotic eluting bone void fillers for pedal osteomyelitis.

RESET-2 phase two

This follow on study explores patients’ experiences of remotely supervised exercise for peripheral arterial disease.

https://www.hra.nhs.uk/planning-and-improving-research/application-summaries/research-summaries/reset2-phase-2-patient-experience-of-remotely-supervised-exercise/

RESET-2 NCT04925219

This randomised controlled trial examined remotely supervised exercise versus self-directed exercise for peripheral arterial disease using a walking tracker.

https://www.hra.nhs.uk/planning-and-improving-research/application-summaries/research-summaries/reset2/

Cerament study

This was the first two arm observational study looking at outcomes after antibiotic eluting bone void fillers versus long term systemic antibiotics for pedal osteomyelitis.

Venkateswaran, V., Tiruveedhula, M., Edwards, J., Dindyal, S., Mulcahy, M. and Thapar, SA. (2024) 'Antibiotic Eluting Bone Void Filler Versus Systemic Antibiotics For Pedal Osteomyelitis', The Journal of Foot and Ankle Surgery. Available at: https://doi.org/10.1053/j.jfas.2024.08.010

Meta-analysis of duplex surveillance after lower limb endovascular therapy

This study analysed the existing data on duplex ultrasound after endovascular therapy in preventing major limb amputation.

McKenna, M., Elghazaly, H., Bergman, B., Wingate, L., Robbins, D., Davies, A. H., Thapar, A. (2023) 'Meta-Analysis of Duplex Surveillance Following Lower Limb Endovascular Intervention', Journal of Endovascular Therapy. Available at: https://doi.org/10.1177/15266028231215215

Aortic aneurysm stenting using fusion imaging

Aortic aneurysm stenting using fusion imaging

Popliteal aneurysm stenting using fusion imaging

Popliteal aneurysm stenting using fusion imaging