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Our Pharmaceutical Research Group (PRG) carries out cutting-edge researches in Nanomedicine, Pharmaceutical Technology, Controlled Release and Drug Development.
Our research is carried out mainly in our Multi-Functional SuperLab Complex, including a well-equipped pharmaceutical research lab.
In addition to pharmaceutical technology research, our research focuses on developing innovative drug delivery approaches to reverse Multidrug Resistance (MDR). For example, cancer cells become more resistant and aggressive after repetitive exposure to chemotherapeutics. This has become one of the major hurdles to successful chemotherapy.
The resistant cancer cells are commonly cross-resistant to a wide range of anticancer drugs. Development of a new drug is a very lengthy and expensive process. Therefore, there is an increasing interest in repurposing known drugs into new uses in cancer therapy. Similar multidrug resistance can be also developed by bacteria, leading to challenging infectious diseases.
For more information, contact Dr Mohammad Najlah at mohammad.najlah@aru.ac.uk or +44 (0)1245 684682.
Najlah, M., 2021. Drug repurposing supported by nanotechnology: a promising strategy to fight cancer. Therapeutic Delivery, 12(4), pp. 267-269. doi: 10.4155/tde-2021-0009
Machado, B., Ime. S., Pautrat, W., Frame, J., Najlah, M., 2021. Scientific Validation of Three-Dimensional Stereophotogrammetry Compared to the IGAIS Clinical Scale for Assessing Wrinkles and Scars after Laser Treatment. Scientific Reports (preprint). doi: 10.21203/rs.3.rs-126281/v1
Machado B, Zhang J, Frame J, Najlah M., 2021. Treatment of Scars with Laser-Assisted Delivery of Growth Factors and Vitamin C: A Comparative, Randomised, Double-blind, Early Clinical Trial. Aesthetic Plastic Surgery. doi: 10.1007/s00266-021-02232-4
Said Suliman, A., Khoder, M., Tolaymat, I., Webster, M., Alany, G. R., Wang, W., Elhissi, M. A., Najlah, M., 2021. Cyclodextrin Diethyldithiocarbamate Copper II Inclusion Complexes: A Promising Chemotherapeutic Delivery System Against Chemoresistant Triple Negative Breast Cancer Cell Lines. Pharmaceutics, 13(1), 84. doi: 10.3390/pharmaceutics13010084
Machado, B., Frame, J., Zhang, J., Najlah, M., 2020. Comparative Study on the Outcome of Periorbital Wrinkles Treated with Laser-Assisted Delivery of Vitamin C or Vitamin C Plus Growth Factors: A Randomized, Double-blind, Clinical Trial. Aesthetic Plastic Surgery, in press. doi: 10.1007/s00266-020-02035-z
Khan, I., Yousaf, S., Najlah, M., Ahmed, W., Elhissi, A. 2020. Proliposome powder or tablets for generating inhalable liposomes using a medical nebulizer. Journal of Pharmaceutical Investigation, pp. 1-13. doi: 10.1007/s40005-020-00495-8
Abdallah, B., Elhissi, A., Ahmed, W., Najlah, M. Carbon Nanotubes Drug Delivery System for Cancer Treatment. In: Ahmed, W., et al, Eds. 2020. Advances in Medical and Surgical Engineering. Elsevier Science & Technology, Academic Press: 2020. doi: 10.1016/C2019-0-00476-1
Said Suliman, A., Tom R., Palmer, K., Tolaymat, I., Younes, H., Arafat, B., Elhissi, M. A., Najlah, M. 2020. Physicochemical Characterisation and Stability Evaluation of Ciprofloxacin-Loaded Parenteral Nutrition Nanoemulsions. Pharmaceutical Development and Technology, pp. 1-26. doi: 10.1080/10837450.2020.1720237 (IF 2.347)
Khudair, N,. Agouni, A., Elrayess, M., Najlah, M., Younes, H., Elhissi, A. 2020. Letrozole-loaded nonionic surfactant vesicles prepared via a slurry-based proniosome technology: Formulation development and characterization. Journal of Drug Delivery Science and Technology. doi: 10.1016/j.jddst.2020.101721 (IF 2.734)
Rycerz, K, Stepien, K. A.,Czapiewska, M., Arafat, B. T., 2019. Embedded 3D Printing of Novel Bespoke Soft Dosage Form Concept for Pediatrics. Pharmaceutics, 26;11(12), p. 630. doi: 10.3390/pharmaceutics11120630
Said, R., Arafat, B. T., Mallah, E., 2019. An LC-MS/MS method for determination of triple drugs combination of valsartan, amlodipine and hydrochlorothiazide in human plasma for bioequivalence study, Current Pharmaceutical Analysis. doi: 10.2174/1573412916666191111125807
Najlah, M., Said Suliman, A., Tolaymat, I., Kurusamy, S., Kannappan, V., Elhissi, M. A., Wang, W., 2019. Development of Injectable PEGylated Liposome Encapsulating Disulfiram for Colorectal Cancer Treatment. Pharmaceutics, 11(11), pp. 610-626. doi: 10.3390/pharmaceutics11110610 (IF 4.773)
Omar, H., Hussein, N., Ferraz, A., Najlah, M., Ahmed, W., Taylor, M. T., Elhissi M. A., 2018. Spray-dried proliposome microparticles for high-performance aerosol delivery using a monodose powder inhaler. AAPS PharmSciTech. doi: 10.1208/s12249-018-1058-4 (IF 2.608)
Arafat, B., Qinna, N., Cieszynska, M., Forbes, R. T., Alhnan, M. A., 2018. Tailored on demand anti-coagulant dosing: an in vitro and in vivo evaluation of 3D printed purpose-designed oral dosage forms. Eur J Pharm Biopharm, pii: S0939-6411(17)31106-2.
Arafat, B., Wojsz, M., Isreb, A., Forbes, R. T., Isreb, M., Ahmed, W., Arafat, T., Alhnan, M. A., 2018. Tablet fragmentation without a disintegrant: A novel design approach for accelerating disintegration and drug release from 3D printed cellulosic tablets. Eur J Pharm Sci. 2018 Jun 15;118, pp. 191-199.
Sherer, C., Prabhu, S., Adams, D., Hayes, J., Rowther, F., Tolaymat, I., Warr, T., Snape, T. J., 2018. Towards identifying potent new hits for glioblastoma. MedChemComm, 9(11), pp. 1850-1861. doi: 10.1039/C8MD00436F
Najlah, M., Freeman, S., Khoder, M., Attwood, D., D’Emanuele, A., 2017. In vitro evaluation of the third generation PAMAM dendrimer conjugates. Molecules, 22(10), p. 1661. doi: 10.3390/molecules22101661
Sherer, C., Tolaymat, I., Rowther, F., Warr, T., Snape, T. J., 2017. Preliminary SAR on indole-3-carbinol and related fragments reveals a novel anticancer lead compound against resistant glioblastoma cells. Bioorganic & medicinal chemistry letters, 27(7), pp. 1561-1565. doi: 10.1016/j.bmcl.2017.02.033
Najlah, M., Ahmed, Z., Iqbal, M., Wang, Z., Tawari, P., Wang, W., McConville, C., 2017. Development and characterisation of disulfiram-loaded PLGA nanoparticles for the treatment of non-small cell lung cancer. European Journal of Pharmaceutics and Biopharmaceutics, 112, pp. 224-233. doi: 10.1016/j.ejpb.2016.11.032
Najlah, M., Jain, M., Wan K. W., Ahmed, W., Phoenix A. D., Taylor, K. M. G., Elhissi, A., 2016. Ethanol-based proliposome delivery systems of paclitaxel for in vitro application against brain cancer cells. Journal of Liposome Research, 14, pp. 1-12. doi: 10.1080/08982104.2016.1259628
Najlah, M., Kadam A., Wan, K. W., Ahmed, W., Taylor K. M. G., Elhissi, A., 2016. Novel paclitaxel formulations solubilized by lipid nanoemulsions for brain tumour therapy. International Journal of Pharmaceutics, 506(1-2), pp. 102-109. doi: 10.1016/j.ijpharm.2016.04.027
Alhnan, M. A., Okwuosa, T. C., Sadia, M., Wan, K. .W., Ahmed, W., Arafat, B., 2016. Emergence of 3D Printed Dosage Forms: Opportunities and Challenges. Pharm Res., 33(8), pp. 1817-32.
Tawari, P., Wang, Z., Najlah, M., Tsang, C., Kannappan, V., Liu, P., Mcconville, C., Armesilla, A., Wang, W., 2015. The cytotoxic mechanisms of Disulfiram and copper(II) in cancer cells. Toxicology Research, 4, pp. 1439-1442. doi: 10.1039/C5TX00210A
Najlah, M., Hidayat, K., Mwesigwa, E., Ahmed, W., Al-Obaidi, K., Elhissi A. M. A., 2015. A facile approach to manufacturing non-ionic surfactant nanodipsersions using proniosome technology and high-pressure homogenization. Journal of Liposome Research, 25(1), pp. 32-37. doi: 10.3109/08982104.2014.924140
Najlah, M., Parveen, I., Faheem, A., Ahmed, W., Phoenix A. D., Kevin Taylor M.G., Elhissi, A., 2014. The effects of suspensions particle size on the performance of vibrating-mesh, air-jet and ultrasonic nebulizers. International Journal of Pharmaceutics, 461(1), pp. 234-241. doi: /10.1016/j.ijpharm.2013.11.022