Professor Rupert Bourne

Professor of Ophthalmology

Faculty:Faculty of Health, Education, Medicine and Social Care

School:Medicine

Location: Cambridge

Areas of Expertise: Vision and eye research

Rupert Bourne is a Consultant Ophthalmic Surgeon at Cambridge University Hospitals and Director of their Cambridge Eye Research Centre. He is the National Speciality Lead for Ophthalmology for the National Institute for Health Clinical Research Network.

rupert.bourne@anglia.ac.uk
www.rupertbourne.co.uk

Background

Rupert Bourne trained at Moorfields Eye Hospital and undertook two Glaucoma fellowships, one there and another at the Shiley Eye Centre/Hamilton Glaucoma Center in San Diego, California.

He is the Chair of the National Institute for Health Research Ophthalmology Speciality Group, responsible for NHS research delivery. In his role as Coordinator of the Vision Loss Expert Group of the Global Burden of Disease Study, he has overseen the long-term research into the world-wide prevalence rates of blindness and visual impairment, in partnership with the World Health Organization.

Spoken Languages

  • French

Research interests

Rupert has a strong research interest, particularly in advanced techniques of glaucoma diagnosis and the progression and management of glaucoma in the community.  He is also interested in ophthalmology overseas, which has involved design and analysis of several large population-based surveys of eye disease, several national in scope, eg. Pakistan, Bangladesh and Trinidad. He has set up several de novo glaucoma clinical research studies in the UK as Chief Investigator and has been principal investigator of more than 15 multi-centre clinical trials. Additionally, he has served in a supervisory role and as Chair of Steering Committees of major national studies.


Areas of research supervision

Supervised several PhD, MD and MSc students to completion as primary supervisor.

Teaching

Regularly teaches medical students, optometry students and Ophthalmology residents and fellows on local, regional and national teaching programs and conferences. Faculty of European Glaucoma Society, European School for Advanced Studies in Ophthalmology and World Glaucoma Association.

Qualifications

  • 2005 – Degree of Doctor of Medicine (M.D.), University of London. Entitled: “The morphology of the optic nerve head in two representative South-east Asian populations”. Awarded 31.1.05.
  • 2003 – Royal College of Ophthalmologists Exit Examination.
  • 1999 – Final FRCOphth. Fellow Royal College of Ophthalmologists, UK.
  • 1996 – Part II.  FRCOphth.
  • 1996 – Part I. FRCOphth.
  • 1994 -  MB BS. University of London, UK.
  • 1993 - United States Medical Licensing Examination Steps 1 & 2.
  • 1991 – 1st Class Honours Bachelor of Science degree (Pathology and Basic Medical Sciences)

Memberships, editorial boards

  • The Royal College of Ophthalmologists
  • The Association for Research in Vision and Ophthalmology (ARVO)
  • World Glaucoma Association
  • European Glaucoma Society
  • European School for Advanced Studies in Ophthalmology
  • Section Editor, for Eye, the journal of The Royal College of Ophthalmologists

Awards

  • 2003 - Winner of Royal Society of Medicine; Ophthalmology section: best overall presentation
  • 2003 - Pharmacia ARVO Travel Award
  • 2000 - Singapore National Eye Centre conference. (oral presentation). Best paper award. The Use of the Heidelberg Retinal Tomograph - II in a population-based glaucoma survey
  • 1993 - The Medical Society of London (Sir John McNee Bequest) award for medical elective: Vaccination rates in Moscovite children. Report published in Transactions of this Society. Also for medical elective work: 3M Riker Prize & ICI Prize
  • 1993 - George Riddoch Prize for Neurology

Research grants, consultancy, knowledge exchange

As Chief or Principal Investigator (CI/PI)
  • Studies involving OCT & HRT & SLP: diagnostic precision; backwards compatability. Heidelberg Engineering, TFC Frost.
  • UK Glaucoma Treatment Study: site PI (NIHR 5739). Pfizer.
  • Comparative study of new imaging technologies for the diagnosis of glaucoma: the GATE study, site PI. NIHR HTA.
  • MD thesis. Optic nerve morphology in East Asian populations. International Glaucoma Association.
  • Investigating Management of Angle Closure and Treatment study: IMPACT, CI (NIHR 8955). Allergan; NIHR-FSF.
  • Effectiveness in Angle closure Glaucoma of Lens Extraction: EAGLE, site PI. MRC funded.
  • Health Innovation Education Cluster project: Glaucoma Referral refinement pathways in the UK. UK Government: HIEC programme (ARU & UCL collaboration).
  • The Community & Glaucoma Allied Network Glaucoma Evaluation Scheme: CHANGES, CI: Allergan: Diagnostic Innovations Award 2007.
  • Precision Tasks in patients with Glaucoma: collaboration with ARU. NIHR-FSF funding.
  • 24-hour IOP in newly diagnosed glaucoma: collaboration with Papworth sleep laboratory. NIHR-FSF funding & Dora Brown bequest.
  • Prevalence of Sleep Apnoea in Glaucoma: POSAG. NIHR portfolio study with Papworth Sleep Centre, CI. Fight for Sight.
  • Electronic Records – User Requirements, Usability and Workflow Impact: CI (NIHR:12694). UK Government Knowledge Transfer Partnership grant and Medisoft Ltd.
  • Patient Outcome & Experience Measures: PI & CI of recent validation NIHR portfolio study. International Glaucoma Association.
  • The National Ophthalmology Database: Glaucoma Project. International Glaucoma Association.
  • Genetics of Glaucoma: National Eye Survey of Trinidad & Tobago, Co-CI. Govt T&T.
  • Everyday Activities and Fear of Falling in Glaucoma. Fight for Sight, UK.
  • Correlation of signs and symptoms of OSD in Glaucoma. International Glaucoma Association/RCN grant.
  • Contribution of Vision Loss to Global Burden of Disease: Lead for Vision Loss Expert Gp. Bill & Melinda Gates Foundation; Fight for Sight UK.
  • Maintenance of global database on Vision Loss & Visualisations Project. Brien Holden Vision Institute.
  • Pakistan National Eye Survey: CI: Sightsavers International, WHO. Fred Hollows Foundation, Christen Blinden Mission.
  • Bangladesh National Eye Survey: CI: Sightsavers International. British Council for Prevention Blindness.
  • National Eye Survey of Trinidad & Tobago. Co-CI. Govt Trinidad & Tobago; Fight for Sight UK.
  • Prevalence of Glaucoma in Thailand, CI. IGA.
  • Angle closure in Greenland. CI. Gino Watkins Memorial Fund. TFC Frost. Grosserer Christian Andersen og hustru Ingeborg Ovidia Signe Andersen, født Schmidts Legat.

Selected recent publications

Last five years
  1. Manuscript ID bmjopen-2018-026770 - The Feasibility of Fingerprick Autologous Blood (FAB) As a Novel Treatment for Severe Dry Eye Disease (DED): Protocol for a Randomised Controlled Trial, Accepted by BMJ Open 20.9.18
  2. BourneRRA,JonasJB, Bron AM, Cicinelli MV, Das A, Flaxman SR, Friedman DS, Keeffe JE, Kempen JH, Leasher J, Limburg H, Naidoo K, Pesudovs K, Peto T, Saadine J, Silvester AJ, Tahhan N, Taylor HR, Varma R, Wong TY, Resnikoff S; Vision Loss Expert Group of the Global Burden of Disease Study. Prevalence and causes of vision loss in high-income countries and in Eastern and CentralEuropein 2015: magnitude, temporal trends and projections. Br J Ophthalmol. 2018 May;102(5):575-585
  3. Konstantakopoulou E, Gazzard G, Vickerstaff V, Jiang Y, Nathwani N, Hunter R, Ambler G, Bunce C; LiGHT Trial Study Group. The Laser in Glaucoma and Ocular Hypertension (LiGHT) trial. A multicentre randomised controlled trial: baseline patient characteristics. Br J Ophthalmol. 2018 May;102(5):599-603.
  4. Gazzard G, Konstantakopoulou E, Garway-Heath D, Barton K, Wormald R, Morris S, Hunter R, Rubin G, Buszewicz M, Ambler G, Bunce C; LiGHT Trial Study Group. Laser in Glaucoma and Ocular Hypertension (LiGHT) trial. A multicentre, randomised controlled trial: design and methodology.
    Br J Ophthalmol. 2018 May;102(5):593-598
  5. Vickerstaff V, Ambler G, Bunce C, Xing W, Gazzard G; LiGHT Trial Study Group. Erratum to Statistical analysis plan for the Laser-1st versus Drops-1st for Glaucoma and Ocular Hypertension Trial (LiGHT): a multi-centre randomised controlled trial. Trials. 2017 Jul 11;18(1):318.
  6. Vickerstaff V, Ambler G, Bunce C, Xing W, Gazzard G; LiGHT Trial Study Group. Statistical analysis plan for the Laser-1st versus Drops-1st for Glaucoma and Ocular Hypertension Trial (LiGHT): a multi-centre randomised controlled trial. Trials. 2015 Nov 11;16:517.
  7. Foreman et al. Prevalence and Causes of Unilateral Vision Impairment and Unilateral Blindness in Australia. JAMA Ophthalmology Jan2018.
  8. Flaxman SR, Bourne RRA, Resnikoff S, Ackland P, Braithwaite T, Cicinelli MV, Das A, Jonas JB, Keeffe J, Kempen JH, Leasher J, Limburg H, Naidoo K, Pesudovs K, Silvester A, Stevens GA, Tahhan N, Wong TY, Taylor HR; Vision Loss Expert Group of the Global Burden of Disease Study. Globalcauses of blindness and distance vision impairment 1990-2020: a systematic review and meta-analysis. Lancet Glob Health. 2017 Dec;5(12):e1221-e1234.
  9. Ackland P, Resnikoff S, Bourne R. Community Eye Health Journal - Issue 100 - 1988-2018 How far have we come?
  10. Jonas JB, Aung T, Bourne RR, Bron AM, Ritch R, Panda-Jonas S. Glaucoma. Authors´reply.  Reply to the letter-to-the-editor, written by „Salem CB, Fathallah N, Zayani H. Glaucoma“, referring to the article „Jonas JB, Aung T, Bourne RR, Bron AM, Ritch R, Panda-Jonas S. Glaucoma. Lancet 2017;390:2183–2193.“ Lancet 2018;391:740.
  11. Delcourt et al. The decreasing prevalence of non-refractive visual impairment in older Europeans: a meta-analysis of published and unpublished data. Ophthalmology Feb 2018.
  12. Claudia Becker1, Cornelia Schneider1,2, Samuel Aballéa3, Rupert Bourne4, Clare Bailey5, Susan Jick6, Christoph Meier1. Cataract in patients with diabetes mellitus incidence rates in the UK and risk factorsCataract in patients with diabetes mellitus—incidence rates in the UK and risk factors. Eye Jan 2018.
  13. Braithwaite T, Winford B, Bailey H, Bridgemohan P, Bartholomew D, Singh D, Sharma, Sharma R, Silva JC, Gray A, Ramsewak SS, Bourne RRA. Health system dynamics analysis of eyecare services in Trinidad and Tobago and progress towards Vision 2020 Goals.Health Policy and Planning. 30 October 2017
  14. GBD 2016 DALYs and HALE Collaborators. Global, regional, and national disability-adjusted life-years (DALYs) for 333 diseases and injuries and healthy life expectancy (HALE) for 195 countries and territories, 1990-2016: a systematic analysis for the Global Burden of Disease Study 2016. Lancet. 2017 Sep 16;390(10100):1260-1344.
  15. Global, regional, and national incidence, prevalence, and years lived with disability for 328 diseases and injuries for 195 countries, 1990-2016: a systematic analysis for the Global Burden of Disease Study 2016. GBD 2016 Disease and Injury Incidence and Prevalence Collaborators. Lancet. 2017 Sep 16;390(10100):1211-1259.
  16. Global, regional, and national age-sex specific mortality for 264 causes of death, 1980-2016: a systematic analysis for the Global Burden of Disease Study 2016. GBD 2016 Causes of Death Collaborators. Lancet. 2017 Sep 16;390(10100):1151-1210.
  17. Global, regional, and national under-5 mortality, adult mortality, age-specific mortality, and life expectancy, 1970-2016: a systematic analysis for the Global Burden of Disease Study 2016. GBD 2016 Mortality Collaborators. Lancet. 2017 Sep 16;390(10100):1084-1150.
  18. Konstantakopoulou E, Gazzard G, Vickerstaff V, Jiang Y, Nathwani N, Hunter R, Ambler G, Bunce C; LiGHT Trial Study Group. The laser in glaucoma and ocular hypertension (LiGHT) trial. A multicentre randomised controlled trial: baseline patient characteristics. Br J Ophthalmol. 2017 Oct 5
  19. Gazzard G, Konstantakopoulou E, Garway-Heath D, Barton K, Wormald R, Morris S, Hunter R, Rubin G, Buszewicz M, Ambler G, Bunce C; LiGHT Trial Study Group. Laser in Glaucoma and Ocular Hypertension (LiGHT) Trial. A multicentre, randomised controlled trial: design and methodology. Br J Ophthalmol. 2017 Sep 13.
  20. BourneRRA1,Flaxman SR2,Braithwaite T3,Cicinelli MV4,Das A5,Jonas JB6,Keeffe J7,Kempen JH8,Leasher J9,Limburg H10,Naidoo K11,Pesudovs K12,Resnikoff S13,Silvester A14,Stevens GA15,Tahhan N13,Wong TY16,Taylor HR17;Vision Loss Expert Group. Magnitude, temporal trends, and projections of the global prevalence ofblindnessand distance and near vision impairment: a systematic review and meta-analysis. Lancet Glob Health.2017Aug 2.
  21. Virgili G, Michelessi M, Cook J, Boachie C, Burr J,BanisterK, Garway-Heath DF, Bourne RRA, Asorey Garcia A, Ramsay CR, Azuara-Blanco A. Diagnosticaccuracy of optical coherence tomography for diagnosing glaucoma: secondary analyses of theGATEstudy. Br J Ophthalmol. 2017 Aug 30.
  22. Chakravarthy U, Biundo E, Saka RO, Fasser C,BourneR,LittleJA. TheEconomicImpact of Blindness in Europe.Ophthalmic Epidemiol. 2017 Jun 30:1-9.
  23. Wang B1,2Congdon N3,4,5Bourne R6Li Y7Cao K1Zhao A1Yusufu M1Dong W8Zhou M8Wang N1,2. Burden of vision loss associated with eye disease in China 1990–2020: findings from the Global Burden of Disease Study 2015. Br J Ophthalmol. 2017 Jun 12.
  24. The prevalence and causes of vision loss in Indigenous and non-Indigenous Australians: The National Eye Health Survey. Edward Keel, Peter Van Wijngaarden, Sukhpal Singh Sandhu, Brian Ang, Jennifer Chen Chia Fan Gaskin, Jonathan Crowston, Hugh Taylor. Ophthalmology, In Press 2017.
  25. Jost B. Jonas, Tin Aung, Rupert R. Bourne, Alain M. Bron, Robert Ritch, Songhomitra Panda-Jonas. Glaucoma. Lancet 2017;390(10108):2183–2193
  26. Katie Banister, Craig Ramsay, Augusto Azuara-Blanco, Jonathan Cook, Charles Boachie, Jennifer Burr, Manjula Kumarasamy, Rupert Bourne. Challenges in dealing with suspected disease in glaucoma diagnostic accuracy studies. Diagnostic and Prognostic Research 2017, 1(Suppl 1):7.
  27. PardhanS, Scarfe A,BourneR, Timmis M. A Comparison of Reach-to-Grasp and Transport-to-Place Performance in Participants with Age-related Macular Degeneration and Glaucoma. . Invest Ophthalmol Vis Sci.2017Mar 1;58(3):1560-1569.
  28. Braithwaite T, Verlander NQ, Bartholomew D, Bridgemohan P, McNally K, Roach A, Sharma S, Singh D, Pesudovs K, Teelucksingh S, Carrington C, Ramsewak S, Bourne R; NESTT Study Group. The National Eye Survey of Trinidad and Tobago (NESTT): Rationale, Objectives and Methodology. Ophthalmic Epidemiol. 2017 Apr;24(2):116-129.
  29. Bourne RR, Zhekov I, Pardhan S. Temporal ocular coherence tomography-measured changes in anterior chamber angle and diurnal intraocular pressure after laser iridoplasty: IMPACT study. Br J Ophthalmol. 2016 Dec 7 [Epub ahead of print].
  30. Braithwaite T, Taylor H, Bourne R, Keeffe J, Pesudovs K. Does blindness count? Disability weights for vision loss. Clin Exp Ophthalmol. 2016 Nov 11
  31. Bourne RR1, Taylor HR2, Flaxman SR3, Keeffe J4, Leasher J5, Naidoo K6, Pesudovs K7, White RA8, Wong TY9, Resnikoff S10, Jonas JB11; Vision Loss Expert Group of the Global Burden of Disease Study. Number of People Blind or Visually Impaired by Glaucoma Worldwide and in World Regions 1990 - 2010: A Meta-Analysis. PLoS One. 2016 Oct 20;11(10):e0162229. doi: 10.1371/journal.pone.0162229. eCollection 2016.
  32. GBD 2015 Child Mortality Collaborators. Global, regional, national, and selected subnational levels of stillbirths, neonatal, infant, and under-5 mortality, 1980-2015: a systematic analysis for the Global Burden of Disease Study 2015. Lancet. 2016 Oct 8;388(10053):1725-1774
  33. GBD 2015 Risk Factors Collaborators. Global, regional, and national comparative risk assessment of 79 behavioural, environmental and occupational, and metabolic risks or clusters of risks, 1990-2015: a systematic analysis for the Global Burden of Disease Study 2015. Lancet. 2016 Oct 8;388(10053):1659-1724
  34. GBD 2015 DALYs and HALE Collaborators.Global, regional, and national disability-adjusted life-years (DALYs) for 315 diseases and injuries and healthy life expectancy (HALE), 1990-2015: a systematic analysis for the Global Burden of Disease Study 2015. Lancet. 2016 Oct 8;388(10053):1603-1658
  35. GBD 2015 Mortality and Causes of Death Collaborators.Global, regional, and national life expectancy, all-cause mortality, and cause-specific mortality for 249 causes of death, 1980-2015: a systematic analysis for the Global Burden of Disease Study 2015. Lancet. 2016 Oct 8;388(10053):1459-1544
  36. GBD 2015 SDG Collaborators.Measuring the health-related Sustainable Development Goals in 188 countries: a baseline analysis from the Global Burden of Disease Study 2015. Lancet. 2016 Oct 8;388(10053):1813-1850
  37. Naidoo KS, Leasher J, Bourne RR, Flaxman SR, Jonas JB, Keeffe J, Limburg H, Pesudovs K, Price H, White RA, Wong TY, Taylor HR, Resnikoff S; Vision Loss Expert Group of the Global Burden of Disease Study. Global Vision Impairment and Blindness Due to Uncorrected Refractive Error, 1990-2010. Optom Vis Sci. 2016 Mar;93(3):227-34
  38. Allana Roach, Tasanee Braithwaite, Christine Carrington, Elysse Marcellin, Subash Sharma, Aroon Hingorani, Juan Pablo Casas, Michael A. Hauser, R. Rand Allingham, Samuel S. Ramsewak, Rupert Bourne. Addressing ethical challenges in the Genetics Substudy of the National Eye Survey of Trinidad and Tobago (GSNESTT). Appl Transl Genom. 2016 May 12;9:6-14.
  39. Global Estimates on the Number of People Blind or Visually Impaired by Diabetic Retinopathy: A meta-analysis from 1990-2010. Janet Leasher, OD, MPH (1)*, Rupert R. A. Bourne, FRCOphth MD(2)*, Seth R. Flaxman, BA (3), Jost B. Jonas, MD*(4), Jill Keeffe, PhD (5), Kovin Naidoo, OD MPH (6), Konrad Pesudovs, PhD (7), Holly Price, BSc PhD (2), Richard A. White, PhD(8), Tien Y. Wong, MD, PhD (9), Serge Resnikoff, MD, PhD**(10), Hugh R. Taylor, AC MD** (11), on behalf of the Vision Loss Expert Group§ of the Global Burden of Disease Study. Diabetes Care 2016: 39:1643-1649.
  40. Bourne R1, Johnson C, Lawrenson J, Bui BV. Glaucoma: basic science and clinical translation. Ophthalmic Physiol Opt. 2015 Mar;35(2):111-3. doi: 10.1111/opo.12203.
  41. Azuara-Blanco A, Banister K, Boachie C, McMeekin P, Gray J, Burr J, Bourne R, Garway-Heath D, Batterbury M, Hernandez R, McPherson G, Ramsay C, Cook J. Automated imaging technologies for the diagnosis of glaucoma: a comparative diagnostic study for the evaluation of the diagnostic accuracy, performance as triage tests and cost-effectiveness (GATE study). Health Technology Assessment 2016 Feb: 20(8).
  42. Katie Banister1, Charles Boachie2, Rupert Bourne3, Jonathan Cook4, Jennifer M Burr5, Craig Ramsay1, David Garway-Heath6, Joanne Gray7, Peter McMeekin7, Rodolfo Hernández,8 Augusto Azuara-Blanco9. Can automated imaging with HRT for disc and GDx-ECC and Spectralis OCT for retinal nerve fiber layer analysis aid glaucoma detection?Ophthalmology. 2016 May;123(5):930-8
  43. Azuara-Blanco A, Banister K, Boachie C, McMeekin P, Gray J, Burr J, Bourne R, Garway-Heath D, Batterbury M, Hernandez R, McPherson G, Ramsay C, Cook J. Automated imaging technologies for the diagnosis of glaucoma: a comparative diagnostic study for the evaluation of the diagnostic accuracy, performance as triage tests and cost-effectiveness (GATE study). Health Technology Assessment 2016 Feb: 20(8). http://www.journalslibrary.nihr.ac.uk/hta/volume-20/issue-8#abstract
  44. Number of People Blind or Visually Impaired by Cataract Worldwide and in World Regions, 1990 to 2010. Khairallah M, Kahloun R, Bourne R, Limburg H, Flaxman SR, Jonas JB, Keeffe J, Leasher J, Naidoo K, Pesudovs K, Price H, White RA, Wong TY, Resnikoff S, Taylor HR; Vision Loss Expert Group of the Global Burden of Disease Study. Invest Ophthalmol Vis Sci. 2015 Oct 1;56(11):6762-9.
  45. GBD 2013 Mortality and Causes of Death Collaborators. Global, regional, and national age-sex specific all-cause and cause-specific mortality for 240 causes of death, 1990-2013: a systematic analysis for the Global Burden of Disease Study 2013. Lancet. 2015 Jan 10;385(9963):117-71.
  46. Global Burden of Disease Study 2013 Collaborators. Global, regional, and national incidence, prevalence, and years lived with disability for 301 acute and chronic diseases and injuries in 188 countries, 1990-2013: a systematic analysis for the Global Burden of Disease Study 2013. Lancet. 2015 Aug 22;386(9995):743-800.
  47. GBD 2013 DALYs and HALE Collaborators. Global, regional, and national disability-adjusted life years (DALYs) for 306 diseases and injuries and healthy life expectancy (HALE) for 188 countries, 1990-2013: quantifying the epidemiological transition. Lancet. 2015 Nov 28;386(10009):2145-91.
  48. Global, regional, and national comparative risk assessment of 79 behavioural, environmental and occupational, and metabolic risks or clusters of risks in 188 countries, 1990-2013: a systematic analysis for the Global Burden of Disease Study 2013. GBD 2013 Risk Factors Collaborators. Lancet. 2015 Nov 28;386(10009):2145-91.
  49. Brien A Holden,a Nina Tahhan,b Monica Jong,b David A Wilson,b Timothy R Fricke,b Rupert Bournec & Serge Resnikoff.. Towards better estimates of uncorrected presbyopia. Editorial. Bull World Health Organ 2015;93:667
  50. Changes in health in England, with analysis by English regions and areas of deprivation, 1990-2013: a systematic analysis for the Global Burden of Disease Study 2013. Newton JN, Briggs AD, Murray CJ et al with R Bourne as co-author. Lancet. 2015 Dec 5;386(10010):2257-74.
  51. Ratnarajan G, Kean J, French K, Parker M, Bourne R. The false negative rate and the role for virtual review in a nationally evaluated glaucoma referral refinement scheme. Ophthalmic Physiol Opt. 2015 Sep;35(5):577-81.
  52. Sanchez-Parra L, Pardhan S, Buckley RJ, Parker M, Bourne RR. Diurnal Intraocular Pressure and the Relationship With Swept-Source OCT-Derived Anterior Chamber Dimensions in Angle Closure: The IMPACT Study. Invest Ophthalmol Vis Sci. 2015 May 1;56(5):2943-9.
  53. Zheng Li, R Rand Allingham, Masakazu Nakano et al, with R Bourne as co-author. A common variant near TGFBR3 is associated with primary open angle Glaucoma. Hum Mol Genet. 2015 Jul 1;24(13):3880-92
  54. David F Garway-Heath, David P Crabb, Catey Bunce, Gerassimos Lascaratos, Francesca Amalfi tano, Nitin Anand, Augusto Azuara-Blanco, Rupert R Bourne, David C Broadway, Ian A Cunliff e, Jeremy P Diamond, Scott G Fraser, Tuan A Ho, Keith R Martin, Andrew I McNaught, Anil Negi, Krishna Patel, Richard A Russell, Ameet Shah, Paul G Spry, Katsuyoshi Suzuki, Edward T White, Richard P Wormald, Wen Xing, Thierry G Zeyen. Latanoprost for open-angle glaucoma (UKGTS): a randomised, multicentre, placebo-controlled trial. Lancet December 2014.
  55. Ratnarajan G, Somner J, Coombes E, Jones A, Bourne R. The Equity Profile of an Enhanced Optometry scheme. Ophthalmic Physiol Opt. 2015. Mar;35(2):243-4.
  56. Ratnarajan G1, Somner J1, Coombes E2, Jones A2, Bourne R1. Awareness of sight-testing entitlements in patients referred for suspected glaucoma. Eye (Lond). 2014 Apr;28(4):504-5. doi: 10.1038/eye.2014.9. Epub 2014 Feb 7.
  57. Keenan J1, Shahid H, Bourne RR, White AJ, Martin KR. Cambridge community Optometry Glaucoma Scheme. Clin Experiment Ophthalmol. 2014 Jul 28. doi: 10.1111/ceo.12398. [Epub ahead of print]
  58. Jonas JB, Bourne RR, White RA, Flaxman SR, Keeffe J, Leasher J, Naidoo K, Pesudovs K, Price H, Wong TY, Resnikoff S, Taylor HR, on behalf of the Vision Loss Expert Group of the Global Burden of Disease Study.Visual impairment and blindness due to macular diseases globally: A systematic review and meta-analysis. Am J Ophthalmol. 2014 Oct;158(4):808-15
  59. Bourne RRA, Jonas JB, Flaxman SR, Keeffe J, Leasher J, Naidoo K, Parodi M, Pesudovs K, Price H, White RA, Wong TY, Resnikoff S, Taylor HR, on behalf of the Vision Loss Expert Group of the Global Burden of Disease Study. Prevalence and causes of vision loss in high-income countries and in Eastern and Central Europe: 1990-2010. Br J Ophthalmol 2014; 98:629-638
  60. Khairallah M, Kahloun R, Flaxman SR, Jonas JB, Keeffe J, Leasher J, Naidoo K, Pesudovs K, Price H, White RA, Wong TY, Stevens GA*, Resnikoff S*, Taylor HR*, Bourne RR*, on behalf of the Vision Loss Expert Group of the Global Burden of Disease Study. Prevalence and causes of vision loss in North Africa and the Middle East: 1990-2010. Br J Ophthalmol 2014; 98:605-611
  61. Naidoo K, Gichuhi S, Basáñez MG, Flaxman SR, Jonas JB, Keeffe J, Leasher J, Pesudovs K, Price H, Smith J, Turner HC, White RA, Wong TY, Resnikoff S, Taylor HR, Bourne RR, on behalf of the Vision Loss Expert Group of the Global Burden of Disease Study.Prevalence and causes of vision loss in Sub-Saharan Africa: 1990-2010. Br J Ophthalmol 2014; 98:612-618
  62. Leasher JL, Lansingh V, Flaxman SR, Jonas JB, Keeffe J, Naidoo K, Pesudovs K, Price H, Silva JC, White RA, Wong TY, Resnikoff S, Taylor HR, Bourne RR; on behalf of the Vision Loss Expert Group of the Global Burden of Disease Study. Prevalence and causes of vision loss in Latin America and the Caribbean: 1990-2010. Br J Ophthalmol 2014; 98:619-628
  63. Jonas JB, George R, Asokan R, Flaxman SR, Keeffe J, Leasher J, Naidoo K, Pesudovs K, Price H, Vijaya L, White RA, Wong TY, Resnikoff S, Taylor HR, Bourne RR, on behalf of the Vision Loss Expert Group of the Global Burden of Disease Study. Prevalence and causes of vision loss in Central and South Asia: 1990-2010. Br J Ophthalmol 2014; 98:592-598.
  64. Keeffe J, Taylor HR, Pesudovs K, Flaxman SR, Jonas JB,Leasher J, Naidoo K, Price H, White RA, Wong TY, Stevens GA, Resnikoff S, Bourne RR, on behalf of the Vision Loss Expert Group of the Global Burden of Disease Study.Prevalence and causes of vision loss in Southeast Asia and Oceania: 1990-2010. Br J Ophthalmol 2014;98:586-591
  65. Wong TY, Zheng Y, Jonas JB, Flaxman SR, Keeffe J, Leasher J, Naidoo K, Pesudovs K, Price H, White RA, Resnikoff S, Taylor HR, Bourne RR; on behalf of the Vision Loss Expert Group of the Global Burden of Disease Study. Prevalence and causes of vision loss in East Asia: 1990-2010. Br J Ophthalmol 2014; 98:599-604
  66. Bourne RR, Stevens GA, White RA, Smith JL, Flaxman SR, Price H, Jonas JB, Keeffe J, Leasher J, Naidoo K, Pesudovs K, Resnikoff S, Taylor HR; on behalf of the Vision Loss Expert Group. Causes of vision loss worldwide, 1990-2010: a systematic analysis. Lancet Glob Health. 2013 Dec;1(6):e339-e349.
  67. Hotez PJ, Alvarado M, Basáñez MG, Bolliger I, Bourne R, Boussinesq M, Brooker SJ, Brown AS, Buckle G, Budke CM, Carabin H, Coffeng LE, Fèvre EM, Fürst T, Halasa YA, Jasrasaria R, Johns NE, Keiser J, King CH, Lozano R, Murdoch ME, O'Hanlon S, Pion SD, Pullan RL, Ramaiah KD, Roberts T, Shepard DS, Smith JL, Stolk WA, Undurraga EA, Utzinger J, Wang M, Murray CJ, Naghavi M. The global burden of disease study 2010: interpretation and implications for the neglected tropical diseases. PLoS Negl Trop Dis. 2014 Jul 24;8(7):e2865. doi: 10.1371/journal.pntd.0002865. eCollection 2014 Jul.
  68. McGregor, Somner J, Bourne et al. "Social media use by patients with glaucoma: What can we learn?" Ophth Physiol Optics 2014: 34: 46-52.
  69. John EA Somner, Freda Sii, Rupert Bourne, Vinette Cross, Peter Shah. What do patients with glaucoma think about personal health records? Ophth Physiol Opt 2013:33:627-633.
  70. Stevens G, White R, Flaxman SR, Price H, Jonas JB, Keeffe J, Leasher J, Naidoo K, Pesudovs K, Resnikoff S, Taylor H, Bourne R.Global prevalence of visual impairment and blindness: magnitude and temporal trends, 1990-2010. Ophthalmology 2013;120(12):2377-84.
  71. Ratnarajan G, Newsom W, Vernon SA, Fenerty C, Henson D, Spencer F, Wang Y, Harper R, McNaught A, Collins L, Parker M, Lawrenson J, Hudson R, Khaw PT, Wormald R, Garway-Heath D, Bourne R. The effectiveness of schemes that refine referrals between primary and secondary care--the UK experience with glaucoma referrals: the Health Innovation & Education Cluster (HIEC) Glaucoma Pathways Project. BMJ Open. 2013 Jul 21;3(7).
  72. Christopher JL Murray, et al. with R Bourne as co-author. UK health performance: findings of the Global Burden of Disease Study 2010. Lancet 2013: March 5- E pub.
  73. Christopher J L Murray, Michael A Richards, John N Newton, Kevin A Fenton, H Ross Anderson, Charles Atkinson, Derrick Bennett, Eduardo Bernabé, Hannah Blencowe, Rupert Bourne, Tasanee Braithwaite, Carol Brayne, Nigel G Bruce, Traolach S Brugha, Peter Burney, Mukesh Dherani, Helen Dolk, Karen Edmond Majid Ezzati, Abraham D Flaxman, Tom D Fleming, Greg Freedman, David Gunnell, Roderick J Hay, Sally J Hutchings, Summer Lockett Ohno, Rafael Lozano, Ronan A Lyons, Wagner Marcenes, Mohsen Naghavi, Charles R Newton, Neil Pearce, Dan Pope, Lesley Rushton, Joshua A Salomon, Kenji Shibuya, Theo Vos, Haidong Wang, Hywel C Williams,Anthony D Woolf, Alan D Lopez, Adrian Davis. UK health performance: findings of the Global Burden of Disease Study 2010. Lancet 2013: March 5- E pub.
  74. Bourne R, Gale R. The Ophthalmology Specialty Group and the National Institute for Health Research- the first 6 years. Eye 2013; 27:457-60.
  75. Gokulan Ratnarajan, Wendy Newsom, Karen French, Jane Kean, Lydia Chang, Mike Parker, David F Garway-Heath, Rupert RA Bourne. The impact of glaucoma referral refinement criteria on referral to, and first-visit discharge rates from, the hospital eye service: the Health Innovation & Education Cluster (HIEC) Glaucoma Pathways project. Ophthalmic Physiol Opt 2013 (accepted. doi: 10.1111/opo.12029).
  76. Lim SS, Vos T, Flaxman AD, et al. with R Bourne as co-author. A comparative risk assessment of burden of disease and injury attributable to 67 risk factors and risk factor clusters in 21 regions, 1990-2010: a systematic analysis for the Global Burden of Disease Study 2010. Lancet. 2013 Dec 15;380(9859):2224-60.
  77. Murray CJ, Vos T, Lozano R, et al. with R Bourne as co-author. Disability-adjusted life years (DALYs) for 291 diseases and injuries in 21 regions, 1990-2010: a systematic analysis for the Global Burden of Disease Study 2010. Lancet. 2013 Dec 15;380(9859):2197-223.
  78. Vos T, Flaxman AD, et al, with R Bourne as co-author. Years lived with disability (YLDs) for 1160 sequelae of 289 diseases and injuries 1990-2010: a systematic analysis for the Global Burden of Disease Study 2010. Lancet. 2013 Dec 15;380(9859):2163-96.
  79. Salomon JA, Vos T, Hogan DR, with R Bourne as co-author. Common values in assessing health outcomes from disease and injury: disability weights measurement study for the Global Burden of Disease Study 2010. Lancet. 2013 Dec 15;380(9859):2129-43.
  80. Gokulan Ratnarajan, Wendy Newsom, Karen French, Jane Kean, Lydia Chang, Mike Parker, David F Garway-Heath, Rupert Richard Alexander Bourne. The effect of changes in referral behaviour following NICE guideline publication on agreement of examination findings between professionals in an established glaucoma referral refinement pathway: The Health Innovation & Education Cluster (HIEC) Glaucoma Pathways project. Br J Ophthalmol 2013;97(2):210-4.
  81. Rupert Bourne, Holly Price, Hugh Taylor, et al. New Systematic Review Methodology for Visual Impairment and Blindness for the 2010 Global Burden of Disease Study. Ophth Epidemiol 2013;20(1):33-9.

Recent presentations and conferences

As invited speaker/session chair/organiser

Integrating Research into Clinical Practice. R&D Symposium Hinchingbrooke House, 5 April 2017.

Association for Research in Vision & Ophthalmology, 5-11 May 2017

Investigator Meeting Aerie Pharmaceuticals: The MERCURY Study, 19 May 2017.

Royal College of Ophthalmologists Annual Congress 2017, 23-24 May 2017.

European School for Advanced Studies in Ophthalmology, 29 June 2017.

World Galucoma Association Congress, 30 June-1 July 2017.

Retina International meeting at EURETINA, 7 September 2017.

European Glaucoma Society Faculty Members Meeting, 8-9 September 2017.

Global Burden of Disease 20th Anniversary Celebratory Conference, 25-27 September 2017.

European Society of Cataract & Refractive Surgery, 6-10 October 2017.

Steering Committee Meeting for EDNA HTA study, 24 September 2017.

Asia Angle Closure Club, 22-29 November 2017.

AVICCS 2017 – UK-China British Council Researcher Links Workshop: Auditory and Visual Impairments, their Impact and Community Care, 30 November-1 December 2017.

Sustainability in Glaucoma Services, 17 January 2018.

100% Optical conference, 27-29 January 2018.

Sociedad Mexicana de Oftalmología (SMO) y de la misma Asociación Panamericana de Oftalmología (PAAO), 28 Feburary-3 March 2018.

Global Vision Database, Queens University Belfast teaching, 6 March 2018.

Glaucoma Course: European School for Advanced Studies in Ophthalmology, 13 March 2018.

RCOphth NIHR Masterclass, 10 April 2018.

Italian Glaucoma Society, 12-13 April 2018.

Translational Medicine in Ophthalmology: From Theory to Practice, 20 April 2018.

Fight for Sight: Grants Assessment Panel, 24 April 2018.

Association for Research in Vision & Ophthalmology, 28 April-4 May 2018.

England Vision Strategy conference, 17 May 2018.

European Glaucoma Society, 19-22 May 2018.

RCOphth College Congress NIHR Symposium, 23 May 2018.

E3 European Consortium, 8 June 2018.

World Ophthalmology Congress, 16-19 June 2018.

RCOphth Academic SubCommittee, 20 June  2018.

Haag-Streit UK Glaucoma Symposium, 22 June 2018.

NIHR CRN National Ophthalmology Specialty Group Meeting, 7 September 2018.

XXIII Biennial Meeting of the International Society for Eye Research, 10 September 2018.

Manchester Glaucoma Meeting, 19 September 2018.

Regional Ophthalmology teaching: NIHR Roadshow, 5 October 2018.

European School for Advanced Studies in Ophthalmology Retina Academy, 12 October 2018.

Glaucoma Course: European School for Advanced Studies in Ophthalmology, 22 October 2018.

American Academy of Ophthalmology, 27-30 October 2018.

Media experience

Rupert regularly gives television, radio interviews and webinars.