Dr Linda King

Linda’s background is in pathophysiology and biochemistry, specifically focused on myocardial ischaemia and perturbations in glucose metabolism.

[email protected]

Background

Linda has experience of teaching a wide range of biomedical subjects, covering physiology, cell biology, biochemistry and genetics. She has been at ARU for over six years, having previously taught at the University of Cambridge. She completed post-doctoral studies at the University of Oxford and Imperial College, looking at the changes in the heart due to diabetes.

Linda is a member of the Biomedical Research Group.

Areas of research supervision

• Metabolic changes in ischaemic heart disease and diabetes: changes in the insulin signalling cascade brought about by accumulation of fatty acids, and effects on glucose metabolism
• Lipotoxicity-induced changes in insulin signalling
• Pedagogical research - embedding problem-solving in undergraduate courses

Teaching

BSc (Hons) Biomedical Science
Module Leader for Core Biology 1
Module Leader for Core Biology 2
Contributes to Molecular Cell Biology
Contributes to Principles of Genetics
Contributes to Metabolism and its Control
Contributes to Preparation for Research
Contributes to Human Pathology
Contributes to Human Anatomy and Physiology 1
Contributes to Human Anatomy and Physiology 2
Contributes to Physiology of Organ Systems
Contributes to Personal Development Tutorials

Qualifications

• BSc (Hons) in Physiology and Genetics, University of the Witwatersrand
• MSc Medicine, University of Cape Town
• PhD Medicine, University of Cape Town
• PGCert in Higher Education and Learning, Anglia Ruskin University

Memberships, editorial boards

Fellow of the Royal Society of Biology

Selected recent publications

Rolev K, OʼDonovan DG, Coussons P, King L, Rajan MS, 2018. Feasibility Study of Human Corneal Endothelial Cell Transplantation Using an In Vitro Human Corneal Model. Cornea 37(6):778-784 (Impact factor: 2.01)

McRobie HR, King LM, Fanutti C, Symmons MF, Coussons PJ, 2014. Agouti signalling protein is an inverse agonist to the wildtype and agonist to the melanic variant of the melanocortin- 1 receptor in the grey squirrel (Sciurus carolinensis). FEBS letters 588:2335-2343. (Citations: 2; impact factor 3.623)

McRobie HR, King LM, Coussons P, 2014. Agouti signalling protein (ASIP) acts as an inverse agonist to the melanocortin-1 receptor (MC1R) in the wild type grey squirrel (S. carolinensis) and as agonist to the melanic variant (MC1R Delta 24). Journal of investigative dermatology, 134 (8) S2-S2 (impact factor: 6.287)

McRobie HR, King LM, Fanutti C, Coussons PJ, Moncrief ND, Thomas APM, 2014.  Melanocortin 1 receptor (MC1R) gene sequence variation and melanism in the gray (Sciurus carolinensis), fox (Sciurus niger), and red (Sciurus vulgaris) squirrel. Journal of Heredity 105 (3):423-428 (Citations: 8; impact factor: 2.432)

Desrois M, Sidell RJ, Gauguier D, King LM, Radda GK, Clarke K., 2004.  Initial steps of insulin signaling and glucose transport are defective in the type 2 diabetic rat heart. Cardiovascular Research 61:288–296 (Citations: 113; impact factor 5.947)

King LM, Wilkins MR, 2002. Natriuretic peptide receptors and the heart. Heart 87, 4:314-315 (impact factor 4.964)

King LM, Sidell RJ, Wilding JR, Radda GK, Clarke K, 2001. Free fatty acids, but not ketone bodies, protect diabetic rat hearts during low-flow ischemia. American Journal of Physiology: Heart and Circulatory Physiology 280(3): H1173 - H1181 (Citations: 24; impact factor 3.6)