Professor Justin Stebbing

Professor of Biomedical Sciences

Faculty:Faculty of Science and Engineering

School:Life Sciences

Location: Cambridge

Areas of Expertise: Cancer biology

Professor Justin Stebbing is a Professor of Biomedical Sciences at ARU, Cambridge. He was previously a Professor of Cancer Medicine and Oncology at Imperial College, London (2009-2022), specialising in a range of malignancies, their treatment with immunotherapy (breast, GI and lung and clinical trials) and linking the laboratory to the clinic and vice verse. He is now a Visiting Professor there.

justin.stebbing@aru.ac.uk

View Justin's Oncogene profile

Visit Justin's website

View Justin's Imperial College London profile

Visit the Action Against Cancer website

Visit Justin's Phoenix Hospital Group profile

Background

Justin's track record as a clinician scientist has led to more than 650 peer-reviewed papers, more than 50 of which have appeared in journals with an impact factor exceeding 10, the vast majority as first or last author (current H-score on Google Scholar = 84).

He originally studied medicine at Trinity College, Oxford, gaining a first class degree before moving to The Johns Hopkins Hospital in Baltimore, USA then returning to complete training at the Royal Marsden and St Barts Hospitals. In 2007 he was appointed a Senior Lecturer at Imperial College, London and a Consultant Oncologist at Imperial College Healthcare NHS Trust, then a Professor of Cancer Medicine and Oncology in 2009 (he is now a Visiting Professor there).

The nature of Justin's scientific contributions and international leadership in translational research were recognised by being awarded the NIHR’s first research translational professorship, becoming Editor-in-Chief of Oncogene - Springer Nature’s cancer journal - and elected a member of the American Society for Clinical Investigation.

He was also Chair of the Irish Cancer Society and a national charity, Action Against Cancer, was set up to support his research.

Justin originally commenced his translational research career investigating the link between immunology, tumours and viruses, establishing mechanisms of non-progression in disease such as HIV-1. He extended this to cancer, showing how antiretrovirals worked to prevent tumorigenesis at both an individual level and in large cohorts. This occurred as soon as he arrived back in the UK following his residency program at The Johns Hopkins Hospital, and he completed an MRC-funded PhD fellowship on the contribution of viruses and immunity to cancer and its eradication.

His papers on HIV-1 and antiretrovirals (as first or last author he published more than 150 on HIV/cancer, including 30 in journals with an impact factor exceeding 10), showed a reduction in mortality in AIDS-defining cancers and resolution of individual lesions.

Following this, Justin turned his attention to solid cancers, and focused on drug development, non-coding RNAs, kinases and biomarkers. By way of one example, a team he led described for the first time a new gene, LMTK3 (published in Nature Medicine), and went on to establish its place in some of the most central tumorigenic pathways. We are now undertaking a drug-development program across malignancies. This is also designed to increase health and wealth of the nation, establish national/international collaborations and provide training/teaching for scientists, linking their work to the clinic.

In the last few years, work on this kinase alone has led to high impact factor papers as first or last author in the Journal of Clinical Investigation, Gastroenterology, Cell Reports, Science Signaling, PNAS, Molecular and Cellular Proteomics and Genome Research, in differing models, to name a sample.

Justin has also been a Principal Investigator on a large number of clinical studies of novel/innovative compounds but also led the global development of a biosimilar (CT-P6) of the high value drug Herceptin, and it is now available to the developing world cheaply, ensuring equity in low- and middle-income countries.

There has been global media interest in this work over the years and he has been committed to communicating the excitement of biomedical science to lay audiences.

During the pandemic that has affected his own family members, Justin has been motivated with his team to make a difference. Following his Lancet journal publications describing using AI to find a new drug in early 2020 (now cited thousands of times), he led many of the mechanistic, laboratory and global studies leading to baricitinib’s FDA approval in November 2020. The WHO has given it its highest evidence level.

Baricitinib has the greatest mortality benefits of any drug in the pandemic for hospitalized patients with COVID-19. A book he wrote describing the story of its discovery, Witness to Covid, is widely available. It is testament to the broad utility of AI, teamwork and collaboration.

Recent papers Justin has published bring down barriers between industry and academics. To give one example, a recent Science Advances paper he led includes 55 authors from 33 institutions in 12 countries. He was the senior author on an LMTK3 paper in the same issue of Science Advances.

Aligning with his CT-P6 biosimilar work which concerned equitable drug access, baricitinib for COVID-19 as a simple once/daily tablet with a short half-life, no drug-drug interactions, a low cost and few side effects, has lent itself for use in low- and middle-income countries, a key component of his work. He aims to make a difference to the quality and quantity of life of patients, and help turn cancer into a curable disease.

Selected recent publications

Selected papers from the last two years

Peng, L., Wu, Z., Giamas, G., Stebbing, J.*, Liag, F.*, 2022 (in press). Design and reporting of phase III oncology trials with prospective biomarker validation. Journal of the National Cancer Institute. *joint last author.

Sims, J. T., Chang, C. Y., Poorbaugh, J., Daniels, M., Beasley, S., Zhang, L., Rodgers, G., Lena, L., Lacerenza, L., Sposato, B., Dupont, A., Susen, S., Casalini, G., Corbellino, M., Stebbing, J., Krishnan, V., 2022. Longitudinal Assessment of Systemic Steroid Therapy on Hyperinflammatory Endothelial Biomarker Profiles and Serology Responses of COVID-19 Patients. Journal of Translational Medicine, 20, pp. 411.

Lane, R., Cilibrasi, C., Chen, J., Shah, K., Messuti, E., Mazarakis, N. K., Stebbing, J., Critchley, G., Song, E., Simon, T., Giamas, G., 2022. PDGF-R inhibition induces glioblastoma cell differentiation via DUSP1/p38-MAPK signalling. Oncogene, 41, pp. 2749-2763.

Peng, L., Qin, B. D., Xu, S., Yang, X., Yang, J. S., Xiao, K., Stebbing, J., 2022. Risk and incidence of infection with bevacizumab in non-small cell lung cancer. Oncology Research and Treatment, 45, pp. 281-290.

Boiardi, F., Stebbing, J., 2022. Developments in paediatric cancer care throughout the Covid-19 pandemic: lessons from China. The Lancet Regional Health – Western Pacific, 20, 100398.

Peng, L., Wang, Z., Stebbing, J., Yu, Z., 2022. Novel immunotherapeutic drugs for the treatment of lung cancer. Current Opinion in Oncology, 34, pp. 89-94.

Ye, X., Yang, J., Stebbing, J., Peng, L., 2022. Radiation recall pneumonitis triggered by an immune checkpoint inhibitor following re-irradiation in a lung cancer patient. BMC Pulmonary Medicine, 5, pp. 54.

Wang, Z., Zhu, L., Li, L., Stebbing, J., Wang, Z., Peng, L., 2022. Identification of an immune gene-associated prognostic signature in patients with bladder cancer. Cancer Gene Therapy, 29, pp. 494-504.

Peng, L., Zhu, L., Sun, Y., Stebbing, J., Selvaggi, G., Zhang, Y., Zhu, Z., 2022. Targeting ALK rearrangements in NSCLC: Current state of the art. Frontiers in Oncology, 12, 863461.

Salmerón Ríos, S., Cortés Zamora, E. B., Avendaño Céspedes, A., Romero Rizos, L., Sánchez-Jurado, P. M., Sánchez-Nievas, G., Mas Romero, M., Tabernero Sahuquillo, M. T., Blas Señalada, J. J., Murillo Romero, A., García Nogueras, I., Estrella Cazalla, J. D., Andrés-Pretel, F., Lauschke, V. M., Stebbing, J., Abizanda, P., 2022. Immunogenicity after 6 months of BNT162b2 vaccination in frail or disabled nursing home residents: The COVID-A study. Journal of the American Geriatric Society, 70, pp. 650-658.

Richardson, P., Stebbing, J., 2022. Baricitinib as the treatment of choice for hospitalised patients with COVID-19. EClinicalmedicine, 49, 101493.

Richardson, P. J., Robinson, B. W. S., Smith, D. P., Stebbing, J., 2022. The AI-assisted identification and clinical efficacy of baricitinib in the treatment of COVID-19. Vaccines, 10, pp. 951.

Gerratana, L., Pierga, J. Y., Reuben, J. M., Davis, A. A., Wehbe, F. H., Dirix, L., Fehm, T., Nolé, F., Gisbert-Criado, R., Mavroudis, D., Grisanti, S., Garcia-Saenz, J. A., Stebbing, J., Caldas, C., Gazzaniga, P., Manso, L., Zamarchi, R., Bonotto, M., Fernandez de Lascoiti, A., De Mattos-Arruda, L., Ignatiadis, M., Sandri, M. T., Generali, D., De Angelis, C., Dawson, S. J., Janni, W., Carañana, V., Riethdorf, S., Solomayer, E. F., Puglisi, F., Giuliano, M., Pantel, K., Bidard, F. C., Cristofanilli, M., 2022. Modeling the prognostic impact of circulating tumor cells enumeration in metastatic breast cancer for clinical trial design simulation. Oncologist, 27, e561-e570.

Peng, L., Castellano, L., Stebbing, J., Tao, Y., 2022 (in press). A pyroptosis-related lncRNA signature in bladder cancer. Cancer Medicine.

Caddy, G., Stebbing, J., Wakefield, G., Xun, Y. C., 2022. Modelling of nanoparticle distribution in a spherical tumour during and following a local injection. Pharmaceutics, 14, pp. 1615.

Wang, Z., Zhu, L., Li, K., Sun, Y., Giamas, G., Stebbing, J., Yu, Z., Peng, L., 2022. Alternative Splicing Events in Tumor Immune Infiltration in Renal Clear Cell Carcinomas. Cancer Gene Therapy, 29, pp. 494-504.

Zhu, Q., Jiang, M., Li, W., Sun, S., Li, J., Stebbing, J., Liang, X., Peng, L., 2022. A lung cancer patient harboring a rare oncogenic exon 20 V786M mutation responded to a third-generation tyrosine kinase inhibitor: case report and review of the literature. Frontiers in Oncology, 12, 912426.

Shapira, S., Ben Shmon, M., Hay-Levi, M., Shenber, G., Chosen, G., Bannon, L., Tepper, M., Kazanov, D., Seni, J., Lev-Ari, S., Peer, M., Boubas, D., Stebbing, J., Tsiodras, S., Arber, N. A., 2022. platform for attenuating immune hyperactivity using exosomes displaying CD24 (EXO-CD24) in Coronavirus Disease-2019. EMBO Molecular Medicine, 14, e15997.

Stebbing, J., Nievas, G. S., Falcone, M., Youhanna, S., Richardson, P., Ottaviani, S., Shen, J. X., Sommerauer, C., Tiseo, G., Ghiadoni, L., Virdis, A., Monzani, F., Rizos, L. R., Forfori, F., Céspedes, A. A., De Marco, S., Carrozzi, L., Lena, F., Sánchez-Jurado, P. M., Lacerenza, L. G., Cesira, N., Bernardo, D. C., Perrella, A., Niccoli, L., Méndez, L. S., Matarrese, D., Goletti, D., Tan, Y. J., Monteil, V., Dranitsaris, G., Cantini, F., Farcomeni, A., Dutta, S., Burley, S. K., Zhang, H., Pistello, M., Li, W., Romero, M. M., Pretel, F. A., Simón-Talero, R. S., García-Molina, R., Kutter, C., Felce, J. H., Nizami, Z. F., Miklosi, A. G., Penninger, J. M., Menichetti, F., Mirazimi, A., Abizanda, P., Lauschke, V. M., 2021. JAK inhibition reduces SARS-CoV-2 liver infectivity and modulates inflammatory responses to reduce morbidity and mortality. Science Advances, 7, eabe4724.

The above data amongst others (many of which are below), led to an Emergency Use Authorisation by the USA Food and Drug Administration for baricitinib to treat hospitalised patients with COVID-19, nine months after our initial papers in the Lancet and Lancet Infectious Diseases.

Sims, J. T., Krishnan, V., Chang, C.-Y., Engle, S. M., Casalini, G., Rodgers, G. H., Bivi, N., Nickoloff, B. J., Konrad, R. J., de Bono, S., Higgs, R. E., Benschop, R. J., Ottaviani, S., Cardosa, A., Nirula, A., Corbellino, M., Stebbing, J., 2021. Characterization of the Cytokine Storm Reflects Hyperinflammatory Endothelial Dysfunction in COVID-19. Journal of Allergy and Clinical Immunology, 147, pp. 107-111.

Stebbing, J., Lauschke, V., 2021. JAK inhibitors: more than glucocorticoids. New England Journal of Medicine, 385(5), pp. 463-465.

Kalil, A. C., Stebbing, J., 2021. Baricitinib: The first immunomodulatory treatment for COVID-19 to demonstrate mortality reduction in a placebo-controlled double-blind study. The Lancet Respiratory Medicine, S2213-2600(21)00358-1.

Melikhov, O., Kruglova, T., Lytkina, K., Melkonyan, G., Prokhorovich, E., Putsman, G., Rodoman, G., Vertkin, A., Zagrebneva, A., Stebbing, J., 2021. The use of Janus kinase inhibitors in COVID-19: a prospective observational series in 522 individuals. Annals of Rheumatic Diseases, 80, pp. 1245-1246.

Williams, J., Stebbing, J., 2021. COVID-19 and the risk to cancer patients in China. International Journal of Cancer, 148(2), pp. 265-266.

Carli, G., Cecchi, L., Stebbing, J., Parronchi, P., Farsi, A., 2021. Asthma phenotypes, co-morbidities and disease severity in COVID-19: the need for risk stratification. Allergy, 76, pp. 955-960.

Carli, G., Cecchi, L., Stebbing, J., Parronchi, P., Farsi, A.., 2021. Is asthma protective against COVID-19? Allergy, 21, pp. 866-868.

Salmerón Ríos, S., Mas Romero, M., Cortés Zamora, E. B., Tabernero Sahuquillo, M. T., Romero Rizos, L., Sánchez-Jurado, P. M., Sánchez-Nievas, G., Blas Señalada, J. J., García Nogueras, I., Estrella Cazalla, J. D., Andrés-Pretel, F., Murillo Romero, A., Lauschke, V. M., Stebbing, J., Abizanda, P., 2021. Immunogenicity of the BNT162b2 vaccine in frail or disabled nursing home residents: COVID-A study. Journal of the American Geriatric Society, 69, pp. 1441-1447.

Pallett, S. J. C., Denny, S. J., Patel, A., Charani, E., Mughal, N., Stebbing, J., Davies, G. W., Moore, L. S. P., 2021. Point-of-care SARS-CoV-2 serological assays for enhanced case finding in a UK inpatient population. Scientific Reports, 11, 5860.

Boiardi, F., Stebbing, J., 2021. Reducing transmission of SARS-CoV-2 with intranasal prophylaxis. EBioMedicine, 63, 103170.

Friend, T., Stebbing, J., 2021. What is the intermediate host of SARS-CoV-2? Future Virology. Epub ahead of print.

Majra, D., Benson, J., Pitts, C., Stebbing, J., 2021. SARS-CoV-2 superspreader events. Journal of Infection, 82, pp. 36-40.

Lenz, H. J., Richardson, P., Stebbing, J., 2021. The emergence of baricitinib: a story of tortoises versus hares. Clinical Infectious Diseases, 72, pp. 1251-1254.

Abizanda, P., Calbo Mayo, M. M., Mas Romero, M., Cortes Zamora, E. B., Tabernerno Sahuquillo, M. T. T., Romero Rizos, L. R., Sanchez-Jurado, P. M., Sanchez-Nevas, G., Andres-Pretel, F., Lauschke, V. M., Stebbing, J., 2021. Baricitinib significantly reduces 30-day mortality in older adults with severe COVID-19 pneumonia. Journal of the American Geriatric Society, 69, pp. 2752-2758.

Zhang, H., Han, H., He, T., Labbe, K. E., Hernandez-Diaz, A., Chen, H., Velcheti, V., Stebbing, J.*, Wong, K. K., 2021. Clinical Characteristics and Outcomes of COVID-19-Infected Cancer Patients: A Systematic Review and Meta-Analysis. Journal of the National Cancer Institute, 113, pp. 371-380. *joint last author.

Zhang, H., Han, H., He, T., Labbe, K. E., Hernandez-Diaz, A., Chen, H., Velcheti, V., Stebbing, J., Wong, K. K., 2021. Letter in Response to Cottu, Bozec, Basse, and Paoletti. Journal of the National Cancer Institute, 113, pp. 344-345.

Castellano, L., Zagorac, S., de Giorgio, A., Kalisz, M., Casas-Vila, N., Cathcart, P., You, A., Ottaviani, S., Degani, N., Lombardo, Y., Tweedie, A., Nissan, T., Vance, K., Ulitsky, I., Stebbing, J.*, Dabrowska, A.*, 2021. SCIRT lncRNA restrains tumourigenesis by opposing transcriptional programmes of tumour-initiating cells. Cancer Research, 81, pp. 580-593. *joint last author.

Zhu, L. P., Wang, Z. Q., Stebbing, J., Wang, Z. B., Peng, L., 2021. Immunotherapy-related cystitis: case report and review of the literature. Oncotargets and Therapy, 14, pp. 4321-4328.

Jin, R., Peng, L., Jin, Y., Shou, J., Wang, J., Liang, F., Zhao, J., Wu, M., Li, Q., Yan, J., Wu, X., Shao, Y., Stebbing, J., Shen, H., Li, W., Xia, Y., 2021. EGFR-mutated squamous cell lung cancer and its association with outcomes. Frontiers in Oncology, 11, 680684.

Peng, L., Liang, W. H., Mu, D. G., Xu, S., Hong, S. D., Stebbing, J., Lian, F., Xia, Y., 2021. First line treatment options for PDL1 negative non small cell lung cancer: a Bayesian network meta-analysis. Frontiers in Oncology, 11, 657545.

Page, K., Martinson, L. J., Hastings, R. K., Fernandez-Garcia, D., Gleason, K. L. T., Gray, M. C., Rushton, A. J., Goddard, K., Guttery, D. S., Stebbing, J., Coombes, R. C., Shaw, J. A., 2021. Prevalence of ctDNA in early screen-detected breast cancers using highly sensitive and specific dual molecular barcoded mutation assays. Annals of Oncology, S0923-7534.

Peng, L., Stebbing, J., Liang, F., Xia, Y., 2021. Dual immune checkpoint blockade in patients with PDL1 high expressing non-small cell lung cancer: calling an end? Translational Lung Cancer Research, 10, pp. 3858-3860.

Nteliopoulos, G., Page, K., Hills, A., Howarth, K., Emmett, W., Green, E., Martinson, L. J., Fernadez-Garcia, D., Hastings, R., Guttery, D. S., Kenny, L., Stebbing, J., Cleator, S., Rehman, F., Gleason, K. L. T., Sanela, A., Ion, C., Rushton, A. J., Rosenfeld, N., Coombes, R. C., Shaw, J. A., 2021. Comparison of two targeted ultra-deep sequencing technologies for analysis of plasma circulating tumour DNA in endocrine-therapy-resistant breast cancer patients. Breast Cancer Research and Treatment, 188, pp. 465-476.

Friend, T., Stebbing, J., 2021. Profiling circulating tumour cells and cell free DNA together in metastatic colorectal cancer. British Journal of Cancer, 125, pp. 907-908.

Wendler, F., Teodora-Maria, P., Simon, T., Stebbing, J., Giamas, G., 2021. The LMTK-family of kinases: emerging important players in cell physiology and pathogenesis. Biochimica et Biophysica Acta, 1867, 165372.

Cilibrasi, C., Ditsiou, A., Papakyriakou, A., Mavridis, G., Eravci, M., Stebbing, J., Gagliano, T., Giamas, G., 2021. LMTK3 inhibition affects microtubule stability. Molecular Cancer, 20, pp. 53.

Stebbing, J., Baranau, Y. V., Baryash, V., Manikhas, A., Moiseyenko, V., Dzagnidze, G., Zhavrid, E., Boliukh, D., Pikiel, J., Eniu, A. E., Li, R. K., Tiangco, B., Lee, S. J., Kim, S., 2021. Long term efficacy and safety of CT-P6 versus trastuzumab in patients with HER2-positive early breast cancer: final results from a randomized phase III trial. Breast Cancer Research and Treatment, 188, pp. 631-640.

Magbanua, M. J. M., Hendrix, L. H., Hyslop, T., Barry, W. T., Winer, E. P., Hudis, C., Toppmeyer, D., Carey, L. A., Partridge, A. H., Pierga, J. Y., Fehm, T., Vidal-Martínez, J., Mavroudis, D., Garcia-Saenz, J. A., Stebbing, J., Gazzaniga, P., Manso, L., Zamarchi, R., Antelo, M. L., De Mattos-Arruda, L., Generali, D., Caldas, C., Munzone, E., Dirix, L., Delson, A. L., Burstein, H., Qadir, M., Ma, C., Scott, J. H., Bidard, F. C., Park, J. W., Rugo, H. S., 2021. Serial analysis of circulating tumor cells in patients receiving first-line chemotherapy. Journal of the National Cancer Institute, 113, pp. 443-452.

Nteliopoulos, G., Page, K., Hills, A., Howarth, K., Emmett, W., Green, E., Martinson, L. J., Fernadez-Garcia, D., Hastings, R., Guttery, D. S., Kenny, L., Stebbing, J., Cleator, S., Rehman, F., Gleason, K. L. T., Sanela, A., Ion, C., Rushton, A. J., Rosenfeld, N., Coombes, R. C., Shaw, J. A., 2021. Comparison of two targeted ultra-deep sequencing technologies for analysis of plasma circulating tumour DNA in endocrine-therapy-resistant breast cancer patients. Breast Cancer Research and Treatment, 188, pp. 465-476.

Page, K., Martinson, L. J., Fernandez-Garcia, D., Hills, A., Gleason, K. T., Gray, M.C., Rushtonn, A. J., Nteliopoulos, G., Hastings, R. K., Goddard, K., Ions, L. M., Palmieri, C., Ali, S., Stebbing, J., Coombes, R. C., 2021. Circulating tumour DNA profiling from Breast Cancer screening through to metastatic disease. JCO Precision Oncology, 24(5).

Zhu, L., Wang, Z., Sun, Y., Giamas, G., Stebbing, J., Yu, Z., Peng, L., 2021. A prediction model using alternative splicing events and the immune microenvironment signature in lung adenocarcinoma. Frontiers in Oncology, 11, 778637.

Malczewska, A., Frampton, A. E., Mato Prado, M., Ameri, S., Dabrowska, A. F., Zagorac, S., Clift, A. K., Kos-Kudła, B., Faiz, O., Stebbing, J., Castellano, L., Frilling, A., 2021. Circulating MicroRNAs in Small-bowel Neuroendocrine Tumors: A Potential Tool for Diagnosis and Assessment of Effectiveness of Surgical Resection. Annals of Surgery, 274, e1-e9.

Peng, L., Li, J., Wu, J., Xu, B., Wang, Z., Giamas, G., Stebbing, J., Yu, Z., 2021. A pan-cancer analysis of SMARCA4 alterations in human cancers. Frontiers in Oncology, 12, 762598.

Peng, L., Lu, D., Xia, Y., Hong, S., Selvaggi, G., Stebbing, J., Sun, Y., Liang, F., 2021. Efficacy and safety of first line treatment strategies for anaplastic lymphoma kinase-positive non-small cell lung cancer: a Bayesian network meta-analysis. Frontiers in Oncology, 11, pp. 754-768.

Peng, L., Yang, H., Zhao, Y., He, J., Stebbing, J., Chen, B., 2021. Neurolymphomatosis of multifocal peripheral nerves: a case report and review of the literature. Annals of Palliative Medicine, 21, pp. 2256.

Peng, L., Xaio, K., Cui, J., Ye, S.-H., Zhang, Y.-C., Mao, L., Selvaggi, G., Yen, J., Stebbing, J., 2021. Successful treatment with enartinib after alectinib-induced hyperbilirubinemia in ALK-positive NSCLC. Ontargets and Therapy, 25, pp. 3409-3415.

The two pieces below, published in early February 2020, have been cited >1000 times and spurred the international development of baricitinib to treat COVID-19, and its subsequent computer-bench-bedside driven FDA approval.

Richardson, P., Griffin, I., Tucker, C., Smith, D., Oechsle, O., Phelan, A., Stebbing, J., 2020. Baricitinib as potential treatment for 2019-nCoV acute respiratory disease. The Lancet, 395, e30-e31.

Stebbing, J., Phelan, A., Griffin, I., Tucker, C., Oechsle, O., Smith, D., Richardson, P., 2020. COVID-19: combining anti-viral and anti-inflammatory treatments. Lancet Infectious Diseases

Stebbing, J., Zagorac, S., Peng, L., 2020. Managing cancer patients in the COVID-19 era. European Journal of Cancer, 132, pp. 5-7.

Ottaviani, S., Stebbing, J., 2020. What is the best drug to treat COVID-19? The need for randomised trials. Cell Press. Med Cell Press, 1, pp. 9-10.

Peng, L., Yang, J. S., Stebbing, J., 2020. Lessons to Europe from China during the COVID-19 pandemic. British Journal of Cancer, 123, pp. 7-8.

Richardson, P. J., Ottaviani, S., Prelle, A., Stebbing, J., Casalini, G., Carbellino, M., 2020. CNS penetration of potential anti-COVID-19 drugs. Journal of Neurology, 267, pp. 1880-1883.

Richardson, P., Corbellino, M., Stebbing, J., 2020. Baricitinib for COVID-19: a suitable treatment? Lancet Infectious Diseases, 20, pp. 1013-1014.

Stebbing, J., Krishnan, V., de Bono, S., Ottaviani, S., Casalini, G., Richardson, P. J., Monteil, V., Lauschke, V. M., Mirazimi, A., Youhanna, S., Tan, Y. J., Baldanti, F., Sarasini, A., Ross Terres, J. A., Nickoloff, B. J., Higgs, R. E., Rocha, G., Byers, N. L., Schlichting, D. E., Nirula, A., Cardosa, A., Corebellino, M., 2020. Mechanism of baricitinib supports artificial intelligence-predicted testing in COVID-19 patients. EMBO Molecular Medicine, 12, e12697.

Kumleben, N., Bhopal, R., Czypionka, T., Gruer, L., Kock, R., Stebbing, J., Sigler, F., 2020. Test, test, test for COVID-19 antibodies: the importance of sensitivity, specificity and predictive powers. Public Health, 185, pp. 88-90.

Pelisser, M., Thompson, J., Majra, D., Youhanna, S., Stebbing, J.*, Davies, P.*, 2020. Sports balls as potential SARS-CoV-2 transmission vectors. Public Health in Practice. Epub ahead of print. *joint last author.

Peng, L., Xiao, K., Stebbing, J., Wang, W. J., 2020. A real-world disproportionality analysis of FDA Adverse Event Reporting System (FAERS) events for baricitinib. Expert Opinion on Drug Safety, 19, pp. 1505-1511.

Peng, L., Stebbing, J., Wang, W. J., 2020. Reply to letter to the editor: baricitinib and toxicity: a rare occurrence. Expert Opinion on Drug Safety, 19, pp. 1371-1373.

Tabassum, N., Zhang, H., Stebbing, J., 2020. Repurposing fostamatinib to combat SARS-CoV-2 induced acute lung injury. Cell Reports Medicine,1, 100145.

Peng, L., Stebbing, J., Wang, W. J., 2020. Baricitinib and toxicity: a rare occurrence. Expert Opinion on Drug Safety, 2020, 19, pp. 1371-1373.

Qin, B., Xiao, K., Song, X., Yang, J., Zhang, Y., Stebbing, J., Peng, L., 2020. A meta-analysis comparing responses of Asian versus non-Asian cancer patients to PD-1 and PD-L1 inhibitor-based therapy. Oncoimmunology, 9, 1781333.

Jin, Y., Bao, H., Le, X., Fan, X., Tang, M., Shi, X., Zhao, J., Yan, J., Xu, Y., Quek, K., Elamin, Y. Y., Zhang, J., Futreal, P. A., Wistuba, I. I., Heymach, J. V., Lou, G., Shao, L., He, Q., Lin, C., Wu, X., Shao, Y. W., Wang, X., He, J., Chen, Y., Stebbing, J., Chen, M., Zhang, J., Yu, X., 2020. Distinct co-acquired alterations and genomic evolution during TKI treatment in non-small-cell lung cancer patients with or without acquired T790M mutation. Oncogene, 39, pp. 1846-1859.

Huang, Y., Gu, B., Liu, C., Stebbing, J., Gedroyc, W., Thanou, M., Xu, X. Y., 2020. Thermosensitive Liposome-Mediated Drug Delivery in Chemotherapy: mathematical Modelling for Spatio-temporal Drug Distribution and Model-Based Optimisation. Pharmaceutics, 11(12). pii: E637.

Ditsiou, A., Cilibrasi, C., Simigdala, N., Papakyriakou, A., Milton-Harris, L., Vella, V., Nettleship, J. E., Lo, J. H., Soni, S., Smbatyan, G., Ntavelou, P., Gagliano, T., Iachini, M. C., Khurshid, S., Simon, T., Zhou, L., Hassell-Hart, S., Carter, P., Pearl, L. H., Owen, R. L., Owens, R. J., Roe, S. M., Chayen, N. E., Lenz, H. J., Spencer, J., Prodromou, C., Klinakis, A., Stebbing, J.*, Giamas, G.*, 2020. The structure-function relationship of LMTK3. Science Advances, 46: eabc3099. *joint last author.

Stebbing, J., Mainwaring, P., Curigliano, G., Pegram, M., Latymer, M., Bair, A., Rugo, H. S.. Understanding the Role of Comparative Clinical Studies in the Development of Oncology Biosimilars. Journal of Clinical Oncology, 38(10), pp. 1070-1080.

Bhimani, J., Ball, K., Stebbing, J., 2020. Patient-derived xenograft models-the future of personalised cancer treatment. British Journal of Cancer, 122, pp. 600-602.

Peng, L., Mao, Q. Q., Jiang, B., Zhao, Y. L., Teng, X. D., Yang, J. S., Chen, S. Q., Stebbing, J., Hai, J., 2020. Bilateral posterior uveitis and retinal detachment during immunotherapy: case report and review of the literature. Frontiers in Oncology, 10, 549168.

Smith, K., Galazi, M., Openshaw, M. R., Wilson, P., Sarker, S. J., O'Brien, N., Alifrangis, C., Stebbing, J., Shamash, J., 2020. The Use of Transdermal Estrogen in Castrate-resistant, Steroid-refractory Prostate Cancer. Clinical Genitourinary Cancer, 10. pii: S1558-7673(19)30288-5.

Gagliano, T., Shah, K., Gargani, S., Ditsiou, A., Vella, V., Ntafis, V., Bresciani, G., Bienkowska, K., Chen, J., Lao, L., Carter, P., Alsaleem, M., Rakha, E. A., Benstead-Hum, G., O’Hanlon, T., Michael Dean, M., Pearl, F. M. G., Song, E., Green, A. R., Kontoyiannis, D. L., Stebbing, J., Giamas, G., 2020. PIK3Cδ expression by fibroblasts promotes triple-negative breast cancer progression. Journal of Clinical Investigation, 130, pp. 3188-3224.

Tabassum, N., Cereser, B., Stebbing, J., 2020. A cell-cycle signature classifier for pan-cancer analysis. Oncogene, 39, pp. 6041-6042.

Media experience

  1. Potential Treatment For COVID-19 Identified By BenevolentAI Enters Randomised Clinical Trial. BenevolentAI, 10 April 2020.
  2. How A.I. Steered Doctors Toward a Possible Coronavirus Treatment. The New York Times, 30 April 2020.
  3. Rationale for baricitinib’s use in COVID-19 patients demonstrated. MDedge Rheumatology, 24 November 2020.
  4. Potential new treatment for COVID-19 uncovered by BenevolentAI enters trials. TechCrunch, 14 April 2020.
  5. AI-discovered Olumiant could become Covid-19 drug soon. Korea Biomedical Review, 16 September 2020.
  6. Coronavirus death rate could be halved with new blood biomarker tests, say experts. The Telegraph, 14 September 2020.
  7. Ball is not a ‘vector of disease’, new scientific study shows. The Times (and other media outlets), 4 July 2020.
  8. COVID-19 survival among elderly patients could be improved by arthritis drug. Imperial College London, 13 November 2020.
  9. Data Published In Science Advances Shows Baricitinib Reduces COVID-19 Morbidity And Mortality. BenevolentAI, 13 November 2020.
  10. Clinical Data Validates BenevolentAI's AI Predicted Hypothesis For Baricitinib As A Potential Treatment For COVID-19. BenevolentAI, 1 July 2020.
  11. Arthritis drug cuts COVID-19 deaths in hospitalized patients by two-thirds: study. New York Post, 15 November 2020.
  12. The arthritis drug baricitinib may improve COVID-19 survival. MedScape UK, 19 November 2020.
  13. 'Baricitinib': This arthritis drug may improve Covid survival in elderlies. Ummid.com, 16 November 2020.
  14. Covid kills a FIFTH of all cancer patients - with lung and blood cancer sufferers the most at risk. MailOnline, 8 November 2020.
  15. Coronavirus kills one in five cancer patients, research shows. The Telegraph, 7 November 2020.
  16. Cancer patients at increased risk of severe outcomes from COVID-19. Imperial College London, 13 November 2020.
  17. Expert reaction to study looking at delays in cancer treatment and risk of death. Science Media Centre, 4 November 2020.
  18. Lockdown's collateral cancer timebomb: 40 THOUSAND tumours were 'missed' during first year of Covid pandemic - the equivalent of one every 13 minutes... but top experts fear this is just 'the tip of the iceberg'. MailOnline, 20 October 2022.
  19. Delaying motherhood until 30s 'significantly raises breast cancer risk'. The Telegraph, 8 September 2020.
  20. Waiting Until Your 30s To Conceive May Put You At High Risk For Breast Cancer. Babygaga, 10 September 2020.