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Dr Gerald Clesham

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Cardiovascular System Block Lead

Faculty:
Faculty of Health, Medicine and Social Care
School:
School of Medicine
Location:
Chelmsford
Research Supervision:
Yes

Dr Gerald Clesham is a consultant cardiologist specialising in coronary intervention.

Background

Dr Clesham is also chief investigator for a number of local, hypothesis-based research projects including studies on microvascular function in acute myocardial infarction, ST segment resolution in acute myocardial infarction, heart rate responses in interventional cardiologists performing PCI, and high-definition video analysis of arrhythmias.

Research interests

  • Ischaemic heart disease
  • Coronary physiology
  • Electrocardiography in acute myocardial infarction
  • Clinical cardiology
  • Molecular biology and gene therapy in cardiology

Teaching

  • Formerly Royal College Tutor for Medicine, Broomfield Hospital
  • Educational Supervisor, Broomfield Hospital and Essex Cardiothoracic Centre

Qualifications

  • BA, University of Cambridge
  • BM, BCh University of Oxford
  • MA, University of Cambridge
  • MRCP, FRCP Royal College of Physicians, London
  • PhD, University of Cambridge

Memberships, editorial boards

  • Member, British Cardiovascular Society
  • Member, Clinical Standards Group, British Cardiovascular Intervention Society
  • Reviewer for medical journals

Research grants, consultancy, knowledge exchange

  • Medical Research Council (MRC) training fellowship, £126,000

Selected recent publications

Peri-procedural ST segment resolution during primary percutaneous coronary intervention (PPCI) for acute myocardial infarction: predictors and clinical consequences. Karamsis GV, Russhard P, Al Janabi F, Parker M, Davies JR, Keeble TR, Clesham GJ. Journal of Electrocardiology 2017, 51(2), 224-229.

Door to guidewire time to assess the timely delivery of primary percutaneous coronary intervention (PPCI) in the treatment of ST elevation myocardial infarction (STEMI). Al Janabi F, Russhard P, Parker M, Clesham GJ. Acute Cardiac Care, 2018.

Thrombus aspiration in ST-Segment Elevation Myocardial Infarction: An individual patient meta-analysis: Thrombectomy Triallists Collaboration. Karamasis GV, Davies JR, Clesham GJ. Circulation,  2017, 135 e1097-1098.

Patterns of ST segment resolution after guidewire passage and thrombus aspiration in primary percutaneous coronary intervention (PPCI) for acute myocardial infarction. Russard P, Al Janabi F, Parker M, Clesham GJ. Open Heart, 2016, 3, 1-4.

Fishing in the era of TOTAL: Thrombectomy in primary PCI. Karamasis GV, Clesham GJ. Internat J Cardiology, 2015, (189), 91-93

The advantages of a consultant led primary percutaneous coronary intervention service on patient outcome. Showkathali R, Davies JR, Sayer JW, Kelly PA, Aggarwal RK, Clesham GJ. Quarterly Journal of Medicine, 2013, (11), 989-94.

Survey of the use of epinephrine (adrenaline) for anaphylaxix by junior hospital doctors  Jose R, Clesham GJ. Postgraduate Med J, 2007, (983), 610-11.

Clinical implications of ST segment non-resolution after thrombolysis for myocardial infarction. Bhatia L, Clesham GJ, Turner DR. J R Soc Med, 2004, (12), 566-70.

Effect of intravenous heparin on serum levels of endostatin, VEGF and HGF Bhatia L, Clesham GJ, Turner DR. Clin Sci, 2004, (4), 423.

Identification and characterisation of transforming growth factor beta-regulated vascular smooth muscle cell genes. Adam PJ, Clesham GJ, Flynn PD, Weissberg PL. Cytokine, 2000, (4), 348-54.

Gene therapy made difficult. Clesham GJ. Heart, 1998, (4), 313-4.

Expression of endoglin mRNA and protein in human vascular smooth muscle cells.Adam PJ, Clesham GJ, Weissberg PL. Biochem Biophys Res Comm, 1998, (1), 33-37.

High adenoviral loads stimulate NF kappa B dependent gene expression in human vascular smooth muscle cells. Clesham GJ, Adam PJ, Proudfoot D, Flynn PD, Efstathiou S, Weissberg PL. Gene Therapy, 1998, (2), 174-80.

Cardiac Amyloidosis and the use of diuretic and ACE inhibitor therapy in severe heart failure Nash KL, Brij SO, Clesham GJ. Int J Clin Pract, 1997, (6), 384-5.

Echocardiographic assessment of cardiac involvement in systemic AL amyloidosis in relation to whole body amyloid load measured by serum amyloid P (SAP) clearance, Clesham GJ, Vigushin DM, Hawkins PN, Pepys MP, Oakley CM, Nihoyannoupoulos P. American Journal of Cardiology, 1997, (8), 1104-8.

Enhancer stimulation unmasks latent gene transfer after adenovirus-mediated gene delivery into human vascular smooth muscle cells. Clesham GJ, Browne H, Efstathiou S, Weissberg PL. Circulation Research, 1996, (6), 1188-95.

Is vascular smooth muscle cell proliferation beneficial? Weissberg PL, Clesham GJ, Bennett MR. Lancet, 1996, (8997), 305-7.

Beta adrenergic agonists and pulmonary oedema in preterm labour. Clesham GJ. British Medical Journal, 1994, (6923), 260-2.

Meta-iodobenzylguanidine (MIBG) scanning in the diagnosis of phaeochromocytoma Clesham GJ, Kennedy A, Lavender JP, Dollery CT, Wilkins MR. J Human. Hypertension, 1993, (4), 353-6.

Activation of bovine endothelial thromboxane receptors triggers release of prostacyclin but not EDRF Clesham G, Parsaee H, Joseph S, McEwan JR, MacDermot.  Cardiovascular Research, 1992, 26(5), 513-517.

Recent presentations and conferences

Invited faculty member at national meetings

Advanced Coronary Intervention (ACI), London, January 2012.

Advanced Coronary Intervention (ACI), London, January 2013.

Advanced Coronary Intervention (ACI), London, January 2014.

Complex Coronary Intervention (CCI), Newcastle, June 2016.

Complex Coronary Intervention (CCI), Newcastle, June 2017.

Bifurcation Lesion Treatment (BLT), Manchester October 17.