Gavin has broad basic and translational research experience in the fields of molecular oncology, genomics and histopathology within the NHS, academia and industry. He takes a student-focused approach to teaching, creating an inspiring learning environment that is inclusive and supportive.
Gavin joined the School of Life Sciences in 2021. He is a Cancer Biologist, with a broad research experience and interests that cover numerous aspects of cancer including development, invasion/migration, diagnosis, drug resistance and identification of novel drug targets.
Gavin completed his research training at Imperial College London, being awarded a Masters of Research in Oncology and Cancer Biology and a joint multidisciplinary PhD in Clinical Medicine and Biomedical Engineering. Whilst at Imperial, he developed a comprehensive knowledge of molecular oncology including cancer cell signalling pathways and diagnostics, as well as organic chemistry skills, including the design and development of novel fluorogenic biosensors.
Gavin also completed a postdoctoral research role at the Barts Cancer Institute, London. Research explored stem cell evolution and progression to cancer in disease states that predispose to adenocarcinoma, via histopathological means. Gavin has also previously been employed within the medical devices industry, the NHS, and the medical regulatory industry.
Gavin is an author on numerous peer-reviewed journals, and is also an active member of the board of trustees for the leukodystrophy charity, Alex TLC.
Waddingham, W., Cross, W. C. H., Metcalf, G., Sekine, S., Jansen, M., 2019. Quantifying the Clonal Expansion of Gastric Intestinal Metaplasia in vivo at Single Cell Resolution. Journal of Pathology, 248, S5-S5.
Al Sulaiman, D., Metcalf, G., Ladame., S, 2017. Engineering innovative solutions to screen for prostate cancer. Convergent Science Physical Oncology, 3, 016001. doi: 10.1088/2057-1739/aa5ebe
Metcalf, G. et al., 2016. Amplification-free detection of circulating microRNA biomarkers from body fluids based on fluorogenic oligonucleotide-templated reaction between engineered Peptide Nucleic Acid probes: application to prostate cancer diagnosis. Analytical Chemistry, 88, pp. 8091-8098. ACS Editors’ Choice. doi: 10.1021/acs.analchem.6b01594
Choi, Y., Metcalf, G., Haj Sleiman, M., Vair-Turnbull, D., Ladame, S., 2014. Oligonucleotide-templated reactions based on Peptide Nucleic Acid (PNA) probes: concept and biomedical applications. Bioorganic & Medicinal Chemistry, 22, pp. 4395-4398. doi: 10.1016/j.bmc.2014.05.071
Metcalf, G., 2014. Early Warnings: Molecular probes that identify the ‘signature’ molecules of cancer. The Biologist, 61(6), pp. 29-31.