Professor Dingchang Zheng

Professor of Medical Technology and Innovation

Vision and Eye Research Institute

Faculty:Faculty of Health, Education, Medicine and Social Care

School:School of Allied Health

Location: Chelmsford

Areas of Expertise: Health, social care and medical innovation , Vision and eye research

Research Supervision:Yes

Professor Zheng has been engaged in developing novel medical technologies since 2002 at multidisciplinary groups in both university and hospital environments.

dingchang.zheng@aru.ac.uk

Background

Professor Zheng works across multidisciplinary areas with electronic engineers, medical physicists, computer scientists, clinical consultants, industrial partners, guideline makers, and allied professionals at different stages along the pathway of medical device development and commercialization. He has earned his reputation in research and development of novel cardiovascular technologies and devices with scientific and socioeconomic impacts to address unmet clinical needs, particularly in novel blood pressure and arterial stiffness measurement techniques, and recent developments on monitoring devices and systems using cardiovascular parameters for early detection of pre-term labor, pregnancy induced hypertension, pneumonia and sleep apnoea.

Research interests

  • Innovative medical technology and device development
  • Physiological measurement, physiological signal processing and their clinical application

Areas of research supervision

  • Medical technology innovation
  • Physiological signal processing
  • Physiological system modelling
  • Clinical assessment of innovative medical technology

Qualifications

  • PhD in Medical Physics, Faculty of Medical Sciences, Newcastle University, UK
  • BEng in Biomedical Engineering, College of Biomedical Engineering and Instrument Science, Zhejiang University, China

Memberships, editorial boards

  • Member, Institution of Engineering and Technology (IET)

Research grants, consultancy, knowledge exchange

Research grants, consultancy, knowledge exchange

  • 2017-2019: Bill & Melinda Gates Foundation Grand Challenge: Development of a uterine electrohysterogram system to predict preterm labor for routine clinical use

Editorial boards

  • 2017: Lead Guest Editor, Computational and Mathematical Methods in Medicine
  • 2016: International Advisory Editorial Board, Physiological Measurement
  • 2015: Lead Guest Editor, Computational and Mathematical Methods in Medicine
  • 2012: Academic Editor, Medicine and Scientific Report
  • 2012: Editorial Board, International Journal of Diabetology & Vascular Disease
  • 2012: Editorial Board, Open Access Journal of Science and Technology
  • 2012: Guest Editor, Computational and Mathematical Methods in Medicine
  • 2009: Editorial Board, Proceedings of Computing in Cardiology

Invited grant reviewer

  • 2015: National Panel Member of Biological and Medical Sciences, Newton Funds (UK)
  • 2015: External Evaluator for EU project proposals
  • 2015: Reviewer to British Council - Newton Funds (UK)
  • 2013: Reviewer to BBSRC - Biology and Biological Sciences Research Council (UK)
  • 2012: Reviewer to Wellcome Trust HICF - Health Innovation Challenge Fund (UK)
  • 2012: Reviewer to MRC - Medical Research Council (UK)
  • 2011: Reviewer to EPSRC - Engineering & Physical Science Research Council (UK)
  • 2009: Reviewer to NSFC - National Natural Science Foundation of China (China)

Selected recent publications

Chen M, Chen A, Si X, Ji M, Zheng D. Peripheral arterial volume distensibility changes with applied external pressure: significant difference between arteries with different compliance. Scientific Report 2017; Article Number: 40545; Doi: 10.1038/srep40545.

Zhang M, Zhang XM, Chen F, Chen A, Dong B, Zheng D. Effects of room environment and nursing experience on clinical blood pressure measurement: an observational study. Blood Press Monit 2017; 22: 79-85.

Wang Y, Cao L, Hao DM, Rong Y, Yang L, Zhang S, Chen F, Zheng D. Effects of force load, muscle fatigue and extremely low frequency magnetic stimulation on EEG signals during side arm lateral raise task. Physiol Meas 2017; 38(5): 745-758.

Cao L, Wang Y, Hao DM, Rong Y, Yang L, Zhang S, Zheng D. Effects of force load, muscle fatigue, and magnetic stimulation on surface electromyography during side arm lateral raise task: A preliminary study with healthy subjects. BioMed Research International 2017; Article ID 8943850, Doi: 10.1155/2017/8943850.

Wang A, Yang L, Wen W, Zhang S, Gu G, Zheng D. Gaussian modelling characteristics changes derived from finger photoplethysmographic pulses during exercise and recovery. Microvasc Res. 2017 Mar 24. pii: S0026-2862(16)30234-5. doi: 10.1016/j.mvr.2017.03.008.

Wang A, Yang L, Wen W, Zhang S, Hao D, Liu Y, Khalid SG, Zheng D. Quantification of radial arterial pulse characteristics changes during exercise and recovery. J Physiol Sci. 2016 Dec 27. doi: 10.1007/s12576-016-0515-7

Xia Y, Yang L, Mao X, Zheng D, Liu CY. Quantification of vascular function changes under different emotion states: A pilot study. Technol Health Care. 2016. [Epub ahead of print]

Yao Y, Xu LS, Sun YX, Fu Q, Zhou SR, He DN, Zhang YH, Guo Li, Zheng D. Validation of an adaptive transfer function method to estimate the aortic pressure waveform. IEEE J Biomed Health Inform 2016; 99: DOI: 10.1109/JBHI.2016.2636223

Chen D, Chen F, Murray A, Zheng D. Respiratory modulation of oscillometric cuff pressure pulses and Korotkoff sounds during clinical blood pressure measurement in healthy adults. BioMedical Engineering OnLine 2016; 15:53. DOI: 10.1186/s12938-016-0169-y

Liu CY, Griffiths C, Murray A, Zheng D. Comparison of stethoscope bell and diaphragm, and of stethoscope tube length, for clinical blood pressure measurement. Blood Press Monit 2016; 21:178-83

Wang Y, Hao DM, Jin L, Zhang S, Yang YM, Bin GY, Zheng D. Regression models for near-infrared measurement of subcutaneous adipose tissue thickness. Physiol Meas 2016; 37: 1024-1034

Zhang Y, Hao DM, Lv XH, Li SW, Tian YQ, Zeng Y, Zheng D. Quantification of MRI and MRS characteristics changes in a rat model at different stage of cerebral ischemia. Neurological Research 2016; May 23: 1-7. DOI: 10.1080/01616412.2016.1181345

Zhang J, Liu CY, Pan CL, Bai M, Zhang J, Peng Y, Zheng D, Zhang Z. Effect of multiple clinical factors on recurrent angina after percutaneous coronary intervention: a retrospective study from 398 ST-segment elevation myocardial infarction patients: an observational study. Medicine (Baltimore). 2016; 95: e5015. DIO: 10.1097/MD.0000000000005015

Xie Y, Breen L, Cherrett T, Zheng D, Allen C. An exploratory study of the reverse exchange system of medical devices in the NHS. Supply Chain Manag Journal 2016; 21:194-215

Li P, Li K, Liu CY, Zheng D, Liu CC. Detection of coupling in short physiological series by a joint distribution entropy method. IEEE TBME 2016; 99: doi: 10.1109/TBME.2016.2515543

Dai L, Zhang Y, Zheng D, Xia L, Gong Y. Role of CaMKII and PKA in early afterdepolarization of human ventricular myocardium cell: A Computational model study. Comput Math Methods Med 2016; Article ID 4576313. doi:10.1155/2016/4576313

Liu CY, Zheng D, Murray A. Arteries stiffen with age, but can retain an ability to become more elastic with applied external cuff pressure. Medicine 2015; 94: e1831

Wang A, Yang L, Liu C, Cui J, Li Y, Yang X, Zhang S, Zheng D. Athletic differences in the characteristics of the photoplethysmographic pulse shape: Effect of maximal oxygen uptake and maximal muscular voluntary contraction. BioMed Res Int 2015; Article ID 752470. doi:10.1155/2014/752470

Lara J, Ogbonmwan I, Oggioni C, Zheng D, Qadir O, Brandt K, Mathers J, Siervo M. Effects of handgrip exercise or beetroot juice on blood pressure, peripheral arterial function and ADMA in overweight older adults: a pilot RCT. Maturitas 2015; 82: 228-235

Li P, Liu CY, Sun X, Zheng D, Wang XP, Liu CC. Assessing the complexity of short-term heart beat interval series by distance distribution entropy. Med Biol Eng Comput 2015; 53: 77-87

Gong Y, GaoY, Lu Z, Zheng D, Deng D, Xia L. Preliminary simulation study of atrial fibrillation ablation procedure based on a detailed human atrial model. J Clin Trials in Cardio 2015; 2: 1-9

Zheng D, Di Marco LY, Murray A. Effect of respiration on Korotkoff sounds and oscillometric cuff pressure pulses during blood pressure measurement. Med Biol Eng Comput 2014; 52: 467-73

Zheng D, Pan F, Murray A. Confirmation of the need to evaluate devices that measure BP during cuff inflation with manual measurements during normal deflation. Blood Press Monit 2014; 19: 120-1

Liu CY, Zheng D, Zhao LN, Liu CC. Gaussian fitting for radial artery pressure waveforms: comparison between normal subjects and heart failure patients. Bio-med Mater Eng 2014; 24: 271-7

Liu CY, Zhuang T, Zhao LN, Chang FL, Liu CC, Wei SS, Li QQ, Zheng D. Analysis of arterial pressure waveforms using Gaussians and two-stage particle swarm optimizer. BioMed Research International 2014; Article ID 923260. doi:10.1155/2014/923260

Chen Z, Mao L, Liu CY, Blake J, Zheng D. Decreased peripheral arterial volume distensibility in patients with branch retinal vein occlusion in comparison with normal subjects. Scientific Reports 2014; Article ID 6685. doi: 10.1038/srep06685

Gu G, Yang L, Liu C, Zhang S, Zheng D. Age and BP associated changes in the Gaussian modelling characteristics of the photoplethysmographic pulse. Exp Clin Cardio 2014; 20: 4943-51

Pan F, Zheng D, He P, Murray A. Does the position or contact pressure of the stethoscope make any difference to clinical blood pressure measurements: an observational study. Medicine 2014; 93: e301

Li P, Liu CY, Wang XP, Zheng D, Li Y, Liu CC. A low-complexity data-adaptive approach for premature ventricular contraction recognition. Signal, Image, Video P 2014; 8:111-120

Di Maria C, Liu CY, Zheng D, Langley P, Murray A. Extracting the foetal heart rate from maternal abdominal recordings: Selection of the optimal principal component. Physiol Meas 2014; 35: 1649-1664

Zheng D, Pan F, Murray A. Effect of mechanical behaviour of the brachial artery on blood pressure measurement during both cuff inflation and cuff deflation. Blood Press Monit 2013; 18: 265-71

Liu CY, Zheng D, Murray A, Liu CC. Modelling carotid and radial artery pulse pressure waveforms by curve fitting with Gaussian functions. Biomed Signal Process 2013; 8: 449-454

Liu CY, Zheng D, Li P, Li B, Murray A, Liu CC. Elastic properties of peripheral arteries in heart failure patients in comparison with normal subjects. J Physiol Sci 2013; 65: 195-201

Liu CY, Li K, Zhao L, Liu F, Zheng D, Liu C, Liu S. Analysis of heart rate variability using fuzzy measure entropy. Comput Biol Med 2013; 43: 100-8

Zheng D, Giovannini R, Murray A. Effect of respiration, talking and small body movements on blood pressure measurement. J Hum Hypertens 2012; 26: 458-62

Xia L, Zheng D, Murray A, Liu F, Ye X, Ning G. Cardiovascular System Modeling, editorial. Comput Math Methods Med 2012, doi:10.1155/2012/583172

Di Marco LY, Duan W, Bojarnejad M, Zheng D, King S, Murray A, Langley P. Evaluation of an algorithm based on single-condition decision rules for binary classification of 12-lead ambulatory ECG recording quality. Physiol Meas 2012; 33: 1435-48

Liu C, Li L, Zhao L, Zheng D, Li P, Liu CC. A combination method of improved impulse rejection filter and template matching for identification of anomalous intervals in electrocardiographic RR sequences. J Med Bio Eng 2012; 32, 245-50

Zheng D, Amoore JN, Mieke S, Murray A. How important is the recommended slow cuff pressure deflation rate for blood pressure measurement? Ann Biomed Eng 2011: 39: 2584-91

Zheng D, Murray A. Peripheral arterial volume distensibility: significant differences with age and blood pressure measured using an applied external pressure. Physiol Meas 2011; 32: 499-512

Zheng D, Amoore JN, Mieke S, Murray A. Estimation of mean arterial pressure from the oscillometric cuff pressure: comparison of different techniques. Med Biol Eng Comput 2011; 49: 33-9

Recent presentations and conferences

Conference organising committee

  • 2017 Co-chair, Sino-UK International Workshop on ‘Physiological Measurement and its Clinical Applications’.
  • 2011 Co-chair, International Conference of Computing in Cardiology, Hangzhou, China.

Invited conference session chair

  • Since 2011, invited session chair for the Annual International Conference of Computing in Cardiology.
  • 2006, 2009, 2012: World Congress on Medical Physics and Biomedical Engineering.

Media experience

Invited journal reviewer
Journals include: American Journal of Physiology-Heart and Circulatory Physiology; Journal of Electrocardiology; Physiol Meas; Medical Engineering and Physics; Journal of Hypertension; IEEE Trans on Biomed Eng; IEEE Trans on Biomed Circ Sys; IEEE Trans on Inf Technol BioMed; Measurement Science Review; Journal of Engineering in Medicine; Journal of Zhejiang University-Science B; Blood Pressure Monit; Computer Methods and Programs in Biomedicine; and Annals Biomed Eng.