This NIHR Portfolio Randomised Controlled Trial randomised one eye of patients with primary angle closure or primary angle closure suspects to laser iridotomy (LPI). The fellow eye remained untreated.
Patients were followed up and if the angle remained gonioscopically closed after laser, there was a further randomisation of these eyes to argon laser iridoplasty (ALPI) or monitoring.
The study has resulted in several publications centring around diurnal pressure in eyes with angle closure, the association of diurnal pressure with degree of angle opening in these patients, and the anatomical effect of ALPI in eyes that have received an iridotomy.
Investigators include several members of the Vision and Eye Research Institute, as well as former PhD student Laura Sanchez Parra. More recently, Dr Ivailo Zhekov has continued the work to investigate dynamic features of the iris in these patients using SWEPT-source OCT techniques.